Genetic analysis of Israel acute paralysis virus: Distinct clusters are circulating in the United States

G. Palacios, J. Hui, P. L. Quan, A. Kalkstein, K. S. Honkavuori, A. V. Bussetti, S. Conlan, J. Evans, Y. P. Chen, D. VanEngelsdorp, H. Efrat, J. Pettis, D. Cox-Foster, E. C. Holmes, T. Briese, W. I. Lipkin

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Abstract

Israel acute paralysis virus (IAPV) is associated with colony collapse disorder of honey bees. Nonetheless, its role in the pathogenesis of the disorder and its geographic distribution are unclear. Here, we report phylogenetic analysis of IAPV obtained from bees in the United States, Canada, Australia, and Israel and the establishment of diagnostic real-time PCR assays for IAPV detection. Our data indicate the existence of at least three distinct IAPV lineages, two of them circulating in the United States. Analysis of representatives from each proposed lineage suggested the possibility of recombination events and revealed differences in coding sequences that may have implications for virulence.

Original languageEnglish (US)
Pages (from-to)6209-6217
Number of pages9
JournalJournal of virology
Volume82
Issue number13
DOIs
StatePublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Palacios, G., Hui, J., Quan, P. L., Kalkstein, A., Honkavuori, K. S., Bussetti, A. V., Conlan, S., Evans, J., Chen, Y. P., VanEngelsdorp, D., Efrat, H., Pettis, J., Cox-Foster, D., Holmes, E. C., Briese, T., & Lipkin, W. I. (2008). Genetic analysis of Israel acute paralysis virus: Distinct clusters are circulating in the United States. Journal of virology, 82(13), 6209-6217. https://doi.org/10.1128/JVI.00251-08