Genetic and immunological complexity of major histocompatibility regions

Fritz H. Bach, Michael B. Widmer, Miriam Segall, Marilyn L. Bach, Jan Klein

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.

Original languageEnglish (US)
Pages (from-to)1024-1027
Number of pages4
JournalScience
Volume176
Issue number4038
DOIs
StatePublished - Jan 1 1972

All Science Journal Classification (ASJC) codes

  • General

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