Genetic control of the serum concentration of an H-2-antigen-like polypeptide chain

Sune Kvist, Jan Klein, Per A. Peterson

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Mouse serum contains a protein complex consisting of at least three polypeptide chains. One of the chains with an approximate molecular weight of 40 000 is similar to the heavy chain of normal H-2 antigens. The serum concentration of this 40 000 dalton chain is under genetic control. Formal genetic analyses in B10.M and B10.S mice, their F1 progeny and in backcrosses show that there are two codominantly expressed alleles at a single locus regulating the serum concentration. Measurements of the 40 000 dalton chain in recombinant mice suggest that the controlling locus is situated to the right of the S region.

Original languageEnglish (US)
Pages (from-to)499-507
Number of pages9
Issue number5
Publication statusPublished - Oct 1980


All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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