Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice

Arimantas Lionikas, David A. Blizard, David John Vandenbergh, Joseph T. Stout, George P. Vogler, Gerald E. McClearn, Lars Larsson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The main goal of the study was to explore the genetic architecture underlying muscle weight in old mice. Weight of soleus, tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius muscles was measured in the C57BL/6J (B6) and DBA/2J (D2) strains and derivative generations: a panel of the BXD recombinant inbred (RI) strains and a B6D2 F2 intercross at the age of 800 days. The between-strain difference in muscle weight (B6 > D2) ranged between 16% and 38%. Linkage analysis identified suggestive quantitative trait loci (QTL) on Chromosomes (Chr) 2, 6, 7, 8, 19, and X that influenced muscle weight in the 800-day-old group. Comparison of weights at 200, 500, and 800 days revealed a variable effect of age among the four muscles. Linkage analysis in the B6D2 F2 population combined across the three different age groups identified muscle-, sex-, and age-specific QTL on Chr 1, 2, 3, 5, 6, 8, 9, 11, 13, 17, X, and Y. Genetic factors that influence the rate of weight change (within-strain weight difference at two ages) over the lifespan of BXD RIs were mapped to the markers D2Mit369 and D3Mit130 at the genome-wide p < 0.05 for TA muscle in males (between 200 and 800 days) and females (between 500 and 800 days), respectively. Analysis of all age groups supported previous findings that the genetic effects may be muscle-, age-, and sex-specific.

Original languageEnglish (US)
Pages (from-to)615-628
Number of pages14
JournalMammalian Genome
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2006

Fingerprint

Skeletal Muscle
Weights and Measures
Muscles
Chromosomes, Human, Pair 2
Quantitative Trait Loci
Age Groups
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 1
Genome
Population

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Lionikas, A., Blizard, D. A., Vandenbergh, D. J., Stout, J. T., Vogler, G. P., McClearn, G. E., & Larsson, L. (2006). Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice. Mammalian Genome, 17(6), 615-628. https://doi.org/10.1007/s00335-005-0177-x
Lionikas, Arimantas ; Blizard, David A. ; Vandenbergh, David John ; Stout, Joseph T. ; Vogler, George P. ; McClearn, Gerald E. ; Larsson, Lars. / Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice. In: Mammalian Genome. 2006 ; Vol. 17, No. 6. pp. 615-628.
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Lionikas, A, Blizard, DA, Vandenbergh, DJ, Stout, JT, Vogler, GP, McClearn, GE & Larsson, L 2006, 'Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice', Mammalian Genome, vol. 17, no. 6, pp. 615-628. https://doi.org/10.1007/s00335-005-0177-x

Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice. / Lionikas, Arimantas; Blizard, David A.; Vandenbergh, David John; Stout, Joseph T.; Vogler, George P.; McClearn, Gerald E.; Larsson, Lars.

In: Mammalian Genome, Vol. 17, No. 6, 01.06.2006, p. 615-628.

Research output: Contribution to journalArticle

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