Genetic dissection of proteoglycan function in Drosophila and C. elegans

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Genetic analysis of the signaling pathways that govern patterning during development in the fruitfly Drosophila melanogaster and in the nematode C. elegans have provided insight into the in vivo functions of proteoglycans and their associated glycosaminoglycans. These studies have shown that patterning events dictated by Fibroblast Growth Factor Receptors, Wnt, Transforming Growth Factor-β(TGF-β), and Hedgehog families of growth factors are regulated by proteoglycans. Recent biochemical and structural analyses have shown that the molecular machinery of glycosaminoglycan biosynthesis is highly conserved between these invertebrate organisms and mammals. Drosophila and C. elegans therefore provide powerful model systems for exploring the varied functions proteoglycans and their glycosaminoglycan modifications.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume12
Issue number2
DOIs
StatePublished - Jan 1 2001

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Proteoglycans
Glycosaminoglycans
Drosophila
Dissection
Fibroblast Growth Factor Receptors
Hedgehogs
Transforming Growth Factors
Invertebrates
Drosophila melanogaster
Mammals
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

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Genetic dissection of proteoglycan function in Drosophila and C. elegans. / Selleck, Scott B.

In: Seminars in Cell and Developmental Biology, Vol. 12, No. 2, 01.01.2001, p. 127-134.

Research output: Contribution to journalArticle

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