Genetic effects of FTO and MC4R polymorphisms on body mass in constitutional types

Jong Y. Kim, Seongwon Cha, Imhoi Koo, Byung L. Park, Sangkyun Jeong, Sun M. Choi, Kil S. Kim, Hyoung D. Shin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings into four types through states of physiological imbalances and responsiveness to herbal medicine. One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance toward preserving energy. Common variants of fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index (BMI) by affecting energy intake. Here, we statistically examined the association of FTO and MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle intervention. The increased BMI replicated the association with FTO haplotypes (effect size < 1.1kg/m 2) and MC4R variants (effect size < 0.64kg/m2). After the lifestyle intervention, the carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose more waist-to-hip ratio (0.76%) than non-carriers. The constitutional discrepancy for the accumulation of body mass by the effects of FTO and/or MC4R variants seemed to reflect the physique differences shown in each group of SCM constitutional types. In conclusion, FTO and MC4R polymorphisms appear to play an important role in weight gain, while only FTO variants play a role in weight loss after lifestyle intervention. Different trends were observed among individuals of SCM types, especially for weight gain. Therefore, classification of individuals based on physiological imbalance would offer a good genetic stratification system in assessing the effects of obesity genes.

Original languageEnglish (US)
Article number106390
JournalEvidence-based Complementary and Alternative Medicine
Volume2011
DOIs
StatePublished - Apr 6 2011

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Receptor, Melanocortin, Type 4
Medicine
Body Mass Index
Life Style
Obesity
Energy Intake
Haplotypes
Weight Gain
Waist-Hip Ratio
Herbal Medicine
Genes
Weight Loss
Fats
Alleles
Population

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

Kim, Jong Y. ; Cha, Seongwon ; Koo, Imhoi ; Park, Byung L. ; Jeong, Sangkyun ; Choi, Sun M. ; Kim, Kil S. ; Shin, Hyoung D. / Genetic effects of FTO and MC4R polymorphisms on body mass in constitutional types. In: Evidence-based Complementary and Alternative Medicine. 2011 ; Vol. 2011.
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abstract = "Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings into four types through states of physiological imbalances and responsiveness to herbal medicine. One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance toward preserving energy. Common variants of fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index (BMI) by affecting energy intake. Here, we statistically examined the association of FTO and MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle intervention. The increased BMI replicated the association with FTO haplotypes (effect size < 1.1kg/m 2) and MC4R variants (effect size < 0.64kg/m2). After the lifestyle intervention, the carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose more waist-to-hip ratio (0.76{\%}) than non-carriers. The constitutional discrepancy for the accumulation of body mass by the effects of FTO and/or MC4R variants seemed to reflect the physique differences shown in each group of SCM constitutional types. In conclusion, FTO and MC4R polymorphisms appear to play an important role in weight gain, while only FTO variants play a role in weight loss after lifestyle intervention. Different trends were observed among individuals of SCM types, especially for weight gain. Therefore, classification of individuals based on physiological imbalance would offer a good genetic stratification system in assessing the effects of obesity genes.",
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Genetic effects of FTO and MC4R polymorphisms on body mass in constitutional types. / Kim, Jong Y.; Cha, Seongwon; Koo, Imhoi; Park, Byung L.; Jeong, Sangkyun; Choi, Sun M.; Kim, Kil S.; Shin, Hyoung D.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2011, 106390, 06.04.2011.

Research output: Contribution to journalArticle

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T1 - Genetic effects of FTO and MC4R polymorphisms on body mass in constitutional types

AU - Kim, Jong Y.

AU - Cha, Seongwon

AU - Koo, Imhoi

AU - Park, Byung L.

AU - Jeong, Sangkyun

AU - Choi, Sun M.

AU - Kim, Kil S.

AU - Shin, Hyoung D.

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