Genetic factors in the etiology and potential management of inflammatory bowel disease

Jie Zhang Wen Jie Zhang, Walter Koltun

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The inflammatory bowel diseases (IBD) are chronic inflammatory conditions affecting the intestines. Investigations into IBD have suggested that both environmental and genetic factors are involved in the pathogenesis of IBD. Based on the evidence accumulated over the last decade, current research into the etiology of IBD has been focused on the concept of an environmental stimulus affecting a genetically susceptible individual. A number of genome-wide linkage analyses using sib pairs have indicated that there are at least 4 chromosomal regions that may contain IBD susceptibility loci, designated as IBD1 (chromosome 16), IBD2 (chromosome 12), IBD3 (chromosome 6) and IBD4 (chromosome 14). Disparities in IBD linkage studies, however, are commonly encountered depending on the populations studied. One of the difficulties in genetic studies of IBD is adequate clinical classification and/or subclassification of the disease. Since IBD is a polygenic disease with complex non-Mendelian patterns of inheritance, it appears that a refined genetic disease model for IBD will be necessary before consensus among various genetic studies may be reached.

Original languageEnglish (US)
Pages (from-to)2-8
Number of pages7
JournalSeminars in Colon and Rectal Surgery
Volume12
Issue number1
StatePublished - Jan 1 2001

Fingerprint

Inflammatory Bowel Diseases
Chromosomes, Human, Pair 16
Inheritance Patterns
Inborn Genetic Diseases
Chromosomes, Human, Pair 6
Genetic Models
Disease Susceptibility
Intestines
Genome
Research
Population

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

Cite this

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title = "Genetic factors in the etiology and potential management of inflammatory bowel disease",
abstract = "The inflammatory bowel diseases (IBD) are chronic inflammatory conditions affecting the intestines. Investigations into IBD have suggested that both environmental and genetic factors are involved in the pathogenesis of IBD. Based on the evidence accumulated over the last decade, current research into the etiology of IBD has been focused on the concept of an environmental stimulus affecting a genetically susceptible individual. A number of genome-wide linkage analyses using sib pairs have indicated that there are at least 4 chromosomal regions that may contain IBD susceptibility loci, designated as IBD1 (chromosome 16), IBD2 (chromosome 12), IBD3 (chromosome 6) and IBD4 (chromosome 14). Disparities in IBD linkage studies, however, are commonly encountered depending on the populations studied. One of the difficulties in genetic studies of IBD is adequate clinical classification and/or subclassification of the disease. Since IBD is a polygenic disease with complex non-Mendelian patterns of inheritance, it appears that a refined genetic disease model for IBD will be necessary before consensus among various genetic studies may be reached.",
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Genetic factors in the etiology and potential management of inflammatory bowel disease. / Wen Jie Zhang, Jie Zhang; Koltun, Walter.

In: Seminars in Colon and Rectal Surgery, Vol. 12, No. 1, 01.01.2001, p. 2-8.

Research output: Contribution to journalReview article

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