Genetic influences on latent inhibition

Thomas J. Gould, Jeanne M. Wehner

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The present study examined the development of latent inhibition in a number of inbred strains of mice. C57BL/6J, DBA/2J, C3H/Ibg, BALB/cByJ, A/J, CBA/J, 129/SvevTac, 129/SvJ, and AKR/J mice were screened for the development of latent inhibition. The latent inhibition paradigm involved 1 day of either 40 preexposures to the conditioned stimulus (CS) or no preexposure. On the following training day, the CS was twice paired with a shock unconditioned stimulus (US). On a subsequent test day, the strength of the CS-US association was measured. Mice preexposed to the CS should show a weaker CS- US association, which would reflect development of latent inhibition. Significant between-strain differences existed. The 129/Svev, C57BL/6, BALB/cByJ, AKR, and DBA/2 mice developed latent inhibition, but 129/SvJ, CBA, A, and C3H mice did not. Thus, genetic variance contributes to variability in the development of latent inhibition.

Original languageEnglish (US)
Pages (from-to)1291-1296
Number of pages6
JournalBehavioral Neuroscience
Volume113
Issue number6
DOIs
StatePublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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