Genetic variation at 9 autosomal microsatellite loci in Asian and Pacific populations

Esteban Parra, Nilmani Saha, Agustinus G. Soemantri, Stephen T. Mcgarvey, Joachim Hundrieser, Mark D. Shriver, Ranjan Deka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Genetic variation at 9 autosomal microsatellite loci (CFS1R, TH01, PLA2A, F13A1, CYP19, LPL, D20S481, D20S473, and D20S604) has been characterized in 16 Asian and Oceanic populations, mostly from mainland and insular Southeast Asia. The neighbor-joining tree and the principal coordinates analysis of the genetic relationships of these populations show a clear separation of Papua New Guinea Highlanders and, to a lesser extent, Malayan aborigines (Orang Asli or Semai) from the rest of the populations. Although the number of markers used in this study appears to be inadequate for clarifying the patterns of genetic relationships among the studied populations, in the principal coordinates analysis a geographic trend is observed in the mainland and insular Southeast Asian populations. Furthermore, in an attempt to contrast the extent of variation between autosomal and Y-chromosome-specific microsatellite loci and to reveal potential differences in the patterns of male and female migrations, we have also compared genetic variation at these 9 autosomal loci with variation observed at 5 Y-chromosome-specific microsatellites in a common set of 14 Asian populations.

Original languageEnglish (US)
Pages (from-to)757-779
Number of pages23
JournalHuman Biology
Volume71
Issue number5
StatePublished - Oct 1 1999

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Microsatellite Repeats
genetic variation
chromosome
microsatellite repeats
loci
Population
Y Chromosome
Y chromosome
genetic relationships
Papua New Guinea
Southeastern Asia
Aromatase
Population Genetics
indigenous peoples
South East Asia
analysis
marker
Southeast Asia
trend
multidimensional scaling

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Parra, E., Saha, N., Soemantri, A. G., Mcgarvey, S. T., Hundrieser, J., Shriver, M. D., & Deka, R. (1999). Genetic variation at 9 autosomal microsatellite loci in Asian and Pacific populations. Human Biology, 71(5), 757-779.
Parra, Esteban ; Saha, Nilmani ; Soemantri, Agustinus G. ; Mcgarvey, Stephen T. ; Hundrieser, Joachim ; Shriver, Mark D. ; Deka, Ranjan. / Genetic variation at 9 autosomal microsatellite loci in Asian and Pacific populations. In: Human Biology. 1999 ; Vol. 71, No. 5. pp. 757-779.
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Parra, E, Saha, N, Soemantri, AG, Mcgarvey, ST, Hundrieser, J, Shriver, MD & Deka, R 1999, 'Genetic variation at 9 autosomal microsatellite loci in Asian and Pacific populations', Human Biology, vol. 71, no. 5, pp. 757-779.

Genetic variation at 9 autosomal microsatellite loci in Asian and Pacific populations. / Parra, Esteban; Saha, Nilmani; Soemantri, Agustinus G.; Mcgarvey, Stephen T.; Hundrieser, Joachim; Shriver, Mark D.; Deka, Ranjan.

In: Human Biology, Vol. 71, No. 5, 01.10.1999, p. 757-779.

Research output: Contribution to journalArticle

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Parra E, Saha N, Soemantri AG, Mcgarvey ST, Hundrieser J, Shriver MD et al. Genetic variation at 9 autosomal microsatellite loci in Asian and Pacific populations. Human Biology. 1999 Oct 1;71(5):757-779.