TY - JOUR
T1 - Genetic variation at twentythree microsatellite loci in sixteen human populations
AU - Deka, Ranjan
AU - Shriver, Mark D.
AU - Yu, Ling Mei
AU - Heidreich, Elisa Mueller
AU - Jin, Li
AU - Zhong, Yixi
AU - McGarvey, Stephen T.
AU - Agarwal, Shyam Swarup
AU - Bunker, Clareann H.
AU - Miki, Tetsuro
AU - Hundrieser, Joachim
AU - Yin, Shih Jiun
AU - Raskin, Salmo
AU - Barrantes, Ramiro
AU - Ferrell, Robert E.
AU - Chakraborty, Ranajit
N1 - Funding Information:
We are thankful to Drs Emöke Szathmáry, Francisco Rothhammer, Peter Smouse, Jeff Long and Gebhard Flatz who generously provided DNA samples from the Dogrib Indian, Pehuenche Indian, New Guinea Highlander and German populations, respectively. We thank Diane Smelser for assisting in the preparation of the manuscript. This research was funded by grants GM45861, GM41399, GM58545 from the National Institutes of Health, SBR9600910 from the National Science Foundation, and 95-IJ-CX-008 and 97-LB-VX-0009 from the National Institute of Justice.
PY - 1999/8
Y1 - 1999/8
N2 - We have analysed genetic variation at 23 microsatellite loci in a global sample of 16 ethnically and geographically diverse human populations. On the basis of their ancestral heritage and geographic locations, the studied populations can be divided into five major groups, viz. African, Caucasian, Asian Mongoloid, American Indian and Pacific Islander. With respect to the distribution of alleles at the 23 loci, large variability exists among the examined populations. However, with the exception of the American Indians and the Pacific Islanders, populations within a continental group show a greater degree of similarity. Phylogenetic analyses based on allele frequencies at the examined loci show that the first split of the present-day human populations had occurred between the Africans and all of the non-African populations, lending support to an African origin of modern human populations. Gene diversity analyses show that the coefficient of gene diversity estimated from the 23 loci is, in general, larger for populations that have remained isolated and probably of smaller effective sizes, such as the American Indians and the Pacific Islanders. These analyses also demonstrate that the component of total gene diversity, which is attributed to variation between groups of populations, is significantly larger than that among populations within each group. The empirical data presented in this work and their analyses reaffirm that evolutionary histories and the extent of genetic variation among human populations can be studied using microsatellite loci.
AB - We have analysed genetic variation at 23 microsatellite loci in a global sample of 16 ethnically and geographically diverse human populations. On the basis of their ancestral heritage and geographic locations, the studied populations can be divided into five major groups, viz. African, Caucasian, Asian Mongoloid, American Indian and Pacific Islander. With respect to the distribution of alleles at the 23 loci, large variability exists among the examined populations. However, with the exception of the American Indians and the Pacific Islanders, populations within a continental group show a greater degree of similarity. Phylogenetic analyses based on allele frequencies at the examined loci show that the first split of the present-day human populations had occurred between the Africans and all of the non-African populations, lending support to an African origin of modern human populations. Gene diversity analyses show that the coefficient of gene diversity estimated from the 23 loci is, in general, larger for populations that have remained isolated and probably of smaller effective sizes, such as the American Indians and the Pacific Islanders. These analyses also demonstrate that the component of total gene diversity, which is attributed to variation between groups of populations, is significantly larger than that among populations within each group. The empirical data presented in this work and their analyses reaffirm that evolutionary histories and the extent of genetic variation among human populations can be studied using microsatellite loci.
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U2 - 10.1007/BF02924561
DO - 10.1007/BF02924561
M3 - Article
AN - SCOPUS:0033272937
VL - 78
SP - 99
EP - 121
JO - Journal of Genetics
JF - Journal of Genetics
SN - 0022-1333
IS - 2
ER -