TY - JOUR
T1 - Genetic variation in immediate and delayed postictal refractory period in rats
AU - Francis, Andrew
AU - Fochtmann, Laura
N1 - Funding Information:
This work was aided by support from NIMH (MH 51581, A.F.; MH 46040, L.F.), a NARSAD Young Investigator's Award (A.F.), and a donation from the Beard Family. We thank Eric Decena, Loft Kline and Matthew Winter for technical assistance, and Dr. James A. Mc-Caughran for critical reading of the manuscript.
PY - 1996/5/20
Y1 - 1996/5/20
N2 - We determined postictal refractoriness in Sprague-Dawley rats by comparing lengths of two suprathreshold ECS seizures given 15 s to 24 h apart. A bimodal (immediate and delayed) decrease in seizure duration was found, suggesting ECS alters mechanisms of seizure termination. Since adenosine is implicated in seizure termination, we determined immediate (30 s) and delayed (24 h) postictal ECS refractoriness in Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats which vary in adenosine properties and initial ECS seizure length. At 30 s, the decrease in seizures did not differ between WKY (144%) and SHR (-36%) rats. At 24 h, SHR rats showed no change while the WKY rats showed a 20% decrease in seizure length (P < 0.01). These two strains also differed in the ability of the adenosine antagonist caffeine (50 mg/kg, i.p.) to prolong ECS seizures (no change for WKY, +13% for SHR, P < 0.001). The results suggest immediate and delayed postictal refractoriness are subject to genetic variation and may depend on central adenosine mechanisms.
AB - We determined postictal refractoriness in Sprague-Dawley rats by comparing lengths of two suprathreshold ECS seizures given 15 s to 24 h apart. A bimodal (immediate and delayed) decrease in seizure duration was found, suggesting ECS alters mechanisms of seizure termination. Since adenosine is implicated in seizure termination, we determined immediate (30 s) and delayed (24 h) postictal ECS refractoriness in Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats which vary in adenosine properties and initial ECS seizure length. At 30 s, the decrease in seizures did not differ between WKY (144%) and SHR (-36%) rats. At 24 h, SHR rats showed no change while the WKY rats showed a 20% decrease in seizure length (P < 0.01). These two strains also differed in the ability of the adenosine antagonist caffeine (50 mg/kg, i.p.) to prolong ECS seizures (no change for WKY, +13% for SHR, P < 0.001). The results suggest immediate and delayed postictal refractoriness are subject to genetic variation and may depend on central adenosine mechanisms.
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U2 - 10.1016/0006-8993(96)00182-5
DO - 10.1016/0006-8993(96)00182-5
M3 - Article
C2 - 8793095
AN - SCOPUS:0029940371
SN - 0006-8993
VL - 721
SP - 150
EP - 154
JO - Brain Research
JF - Brain Research
IS - 1-2
ER -