Genetically altered cancer epigenome

Ming Tang, Huacheng Luo, Jianrong Lu

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Cancer cells exhibit altered epigenome. It is well established that aberrant histone modifications, DNA methylation, and chromatin organization may deregulate oncogenes and tumor suppressors, and contribute significantly to cancer phenotypes. Recent large-scale exome and genome sequencing analyses of thousands of human cancer samples have identified driver mutations in genes encoding chromatin regulatory proteins that directly control chromatin modifications, nucleosome remodeling, and long-range chromatin interactions. These studies reveal a mechanistic link between genetic mutations and epigenetic alterations in cancer, and highlight the genetic basis for perturbed cancer epigenome. This review summarizes the current knowledge on chromatin regulators that are significantly mutated in human cancer, which include MLL1-4, SETD2, NSD1, UTX, SMCX, ARID5B, BAP1, ASXL1, CBP and p300, DNMT3A, TET2, IDH1 and IDH2, the SWI/SNF complex, CHD4, CHD8, CTCF, and the cohesin complex.

Original languageEnglish (US)
Title of host publicationEpigenetic Gene Expression and Regulation
PublisherElsevier Inc.
Pages265-289
Number of pages25
ISBN (Electronic)9780128004715
ISBN (Print)9780127999586
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Tang, M., Luo, H., & Lu, J. (2015). Genetically altered cancer epigenome. In Epigenetic Gene Expression and Regulation (pp. 265-289). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-799958-6.00012-3