Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children

Vidya S. Farook, Lavanya Reddivari, Srinivas Mummidi, Sobha Puppala, Rector Arya, Juan Carlos Lopez-Alvarenga, Sharon P. Fowler, Geetha Chittoor, Roy G. Resendez, Birunda Mohan Kumar, Anthony G. Comuzzie, Joanne E. Curran, Donna M. Lehman, Christopher P. Jenkinson, Jane L. Lynch, Ralph A. DeFronzo, John Blangero, Daniel Hale, Ravindranath Duggirala, Jairam K.P. Vanamala

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Abstract

Background: Dietary intake of phytonutrients present in fruits and vegetables, such as carotenoids, is associated with a lower risk of obesity and related traits, but the impact of genetic variation on these associations is poorly understood, especially in children. Objective: We estimated common genetic influences on serum carotenoid concentrations and obesity-related traits in Mexican American (MA) children. Design: Obesity-related data were obtained from 670 nondiabetic MA children, aged 6-17 y. Serum α- and β-carotenoid concentrations were measured in ∼570 (α-carotene in 565 and β-carotene in 572) of these children with the use of an ultraperformance liquid chromatography-photodiode array. We determined heritabilities for both carotenoids and examined their genetic relation with 10 obesity-related traits [body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL) cholesterol, triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, and homeostasis model assessment of insulin resistance] by using family data and a variance components approach. For these analyses, carotenoid values were inverse normalized, and all traits were adjusted for significant covariate effects of age and sex. Results: Carotenoid concentrations were highly heritable and significant [α-carotene: heritability (h2) = 0.81, P = 6.7 3 10211; β-carotene: h2 = 0.90, P = 3.5 3 10215]. After adjusting for multiple comparisons, we found significant (P ≤ 0.05) negative phenotypic correlations between carotenoid concentrations and the following traits: BMI, WC, FM, and triglycerides (range: α-carotene = 20.19 to 20.12; β-carotene = 20.24 to 20.13) and positive correlations with HDL cholesterol (α-carotene = 0.17; β-carotene = 0.24). However, when the phenotypic correlations were partitioned into genetic and environmental correlations, we found marginally significant (P = 0.051) genetic correlations only between β-carotene and BMI (20.27), WC (20.30), and HDL cholesterol (0.31) after accounting for multiple comparisons. None of the environmental correlations were significant. Conclusions: The findings from this study suggest that the serum carotenoid concentrations were under strong additive genetic influences based on variance components analyses, and that the common genetic factors may influence b-carotene and obesity and lipid traits in MA children.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume106
Issue number1
DOIs
StatePublished - Jul 1 2017

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Farook, V. S., Reddivari, L., Mummidi, S., Puppala, S., Arya, R., Lopez-Alvarenga, J. C., Fowler, S. P., Chittoor, G., Resendez, R. G., Kumar, B. M., Comuzzie, A. G., Curran, J. E., Lehman, D. M., Jenkinson, C. P., Lynch, J. L., DeFronzo, R. A., Blangero, J., Hale, D., Duggirala, R., & Vanamala, J. K. P. (2017). Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children. American Journal of Clinical Nutrition, 106(1), 52-58. https://doi.org/10.3945/ajcn.116.144006