Genome sequence survey identifies unique sequences and key virulence genes with unusual rates of amino acid substitution in bovine Staphylococcus aureus

Lisa L. Herron, Rajit Chakravarty, Christopher Dwan, J. Ross Fitzgerald, James M. Musser, Ernest Retzel, Vivek Kapur

Research output: Contribution to journalArticle

39 Scopus citations


Staphylococcus aureus is a major cause of mastitis in bovine and other ruminant species. We here present the results of a comparative genomic analysis between a bovine mastitis-associated clone, RF122, and the recently sequenced human-associated clones, Mu50 and N315, of Staphylococcus aureus. A shotgun sequence survey of ∼10% of the RF122 genome identified numerous unique sequences and those with elevated rates of nonsynonymous substitution. Taken together, these analyses show that there are notable differences in the genomes of bovine mastitis-associated and human clones of S. aureus and provide a framework for the identification of specific factors associated with host specificity in this major human and animal pathogen.

Original languageEnglish (US)
Pages (from-to)3978-3981
Number of pages4
JournalInfection and Immunity
Issue number7
Publication statusPublished - Jul 2 2002


All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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