Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis

Xiaoxing Li, Xuepeng Duan, Haixiong Jiang, Yujin Sun, Yuanping Tang, Zheng Yuan, Jingkang Guo, Wanqi Liang, Liang Chen, Jingyuan Yin, Hong Ma, Jian Wang, Dabing Zhang

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314 Scopus citations

Abstract

The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes. They are known to play important roles in the specification of tissue types in animals. On the other hand, few plant bHLH proteins have been studied functionally. Recent completion of whole genome sequences of model plants Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa) allows genome-wide analysis and comparison of the bHLH family in flowering plants. We have identified 167 bHLH genes in the rice genome, and their phylogenetic analysis indicates that they form well-supported clades, which are defined as subfamilies. In addition, sequence analysis of potential DNA-binding activity, the sequence motifs outside the bHLH domain, and the conservation of intron/exon structural patterns further support the evolutionary relationships among these proteins. The genome distribution of rice bHLH genes strongly supports the hypothesis that genome-wide and tandem duplication contributed to the expansion of the bHLH gene family, consistent with the birth-and-death theory of gene family evolution. Bioinformatics analysis suggests that rice bHLH proteins can potentially participate in a variety of combinatorial interactions, endowing them with the capacity to regulate a multitude of transcriptional programs. In addition, similar expression patterns suggest functional conservation between some rice bHLH genes and their close Arabidopsis homologs.

Original languageEnglish (US)
Pages (from-to)1167-1184
Number of pages18
JournalPlant physiology
Volume141
Issue number4
DOIs
StatePublished - Aug 2006

All Science Journal Classification (ASJC) codes

  • Physiology
  • Genetics
  • Plant Science

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    Li, X., Duan, X., Jiang, H., Sun, Y., Tang, Y., Yuan, Z., Guo, J., Liang, W., Chen, L., Yin, J., Ma, H., Wang, J., & Zhang, D. (2006). Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis. Plant physiology, 141(4), 1167-1184. https://doi.org/10.1104/pp.106.080580