Genome-wide association of trajectories of systolic blood pressure change

Anne E. Justice, Annie Green Howard, Geetha Chittoor, Lindsay Fernandez-Rhodes, Misa Graff, V. Saroja Voruganti, Guoqing Diao, Shelly Ann M. Love, Nora Franceschini, Jeffrey R. O'Connell, Christy L. Avery, Kristin L. Young, Kari E. North

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: There is great interindividual variation in systolic blood pressure (SBP) as a result of the influences of several factors, including sex, ancestry, smoking status, medication use, and, especially, age. The majority of genetic studies have examined SBP measured cross-sectionally; however, SBP changes over time, and not necessarily in a linear fashion. Therefore, this study conducted a genome-wide association (GWA) study of SBP change trajectories using data available through the Genetic Analysis Workshop 19 (GAW19) of 959 individuals from 20 extended Mexican American families from the San Antonio Family Studies with up to 4 measures of SBP. We performed structural equation modeling (SEM) while taking into account potential genetic effects to identify how, if at all, to include covariates in estimating the SBP change trajectories using a mixture model based latent class growth modeling (LCGM) approach for use in the GWA analyses. Results: The semiparametric LCGM approach identified 5 trajectory classes that captured SBP changes across age. Each LCGM identified trajectory group was ranked based on the average number of cumulative years as hypertensive. Using a pairwise comparison of these classes the heritability estimates range from 12 to 94 % (SE = 17 to 40 %). Conclusion: These identified trajectories are significantly heritable, and we identified a total of 8 promising loci that influence one's trajectory in SBP change across age. Our results demonstrate the potential utility of capitalizing on extant genetic data and longitudinal SBP assessments available through GAW19 to explore novel analytical methods with promising results.

Original languageEnglish (US)
Article number56
JournalBMC Proceedings
Volume10
DOIs
StatePublished - Jan 1 2016

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Blood pressure
Genes
Trajectories
Genome
Blood Pressure
Genome-Wide Association Study
Growth
Education
Sex Factors

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Justice, A. E., Howard, A. G., Chittoor, G., Fernandez-Rhodes, L., Graff, M., Voruganti, V. S., ... North, K. E. (2016). Genome-wide association of trajectories of systolic blood pressure change. BMC Proceedings, 10, [56]. https://doi.org/10.1186/s12919-016-0050-9
Justice, Anne E. ; Howard, Annie Green ; Chittoor, Geetha ; Fernandez-Rhodes, Lindsay ; Graff, Misa ; Voruganti, V. Saroja ; Diao, Guoqing ; Love, Shelly Ann M. ; Franceschini, Nora ; O'Connell, Jeffrey R. ; Avery, Christy L. ; Young, Kristin L. ; North, Kari E. / Genome-wide association of trajectories of systolic blood pressure change. In: BMC Proceedings. 2016 ; Vol. 10.
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title = "Genome-wide association of trajectories of systolic blood pressure change",
abstract = "Background: There is great interindividual variation in systolic blood pressure (SBP) as a result of the influences of several factors, including sex, ancestry, smoking status, medication use, and, especially, age. The majority of genetic studies have examined SBP measured cross-sectionally; however, SBP changes over time, and not necessarily in a linear fashion. Therefore, this study conducted a genome-wide association (GWA) study of SBP change trajectories using data available through the Genetic Analysis Workshop 19 (GAW19) of 959 individuals from 20 extended Mexican American families from the San Antonio Family Studies with up to 4 measures of SBP. We performed structural equation modeling (SEM) while taking into account potential genetic effects to identify how, if at all, to include covariates in estimating the SBP change trajectories using a mixture model based latent class growth modeling (LCGM) approach for use in the GWA analyses. Results: The semiparametric LCGM approach identified 5 trajectory classes that captured SBP changes across age. Each LCGM identified trajectory group was ranked based on the average number of cumulative years as hypertensive. Using a pairwise comparison of these classes the heritability estimates range from 12 to 94 {\%} (SE = 17 to 40 {\%}). Conclusion: These identified trajectories are significantly heritable, and we identified a total of 8 promising loci that influence one's trajectory in SBP change across age. Our results demonstrate the potential utility of capitalizing on extant genetic data and longitudinal SBP assessments available through GAW19 to explore novel analytical methods with promising results.",
author = "Justice, {Anne E.} and Howard, {Annie Green} and Geetha Chittoor and Lindsay Fernandez-Rhodes and Misa Graff and Voruganti, {V. Saroja} and Guoqing Diao and Love, {Shelly Ann M.} and Nora Franceschini and O'Connell, {Jeffrey R.} and Avery, {Christy L.} and Young, {Kristin L.} and North, {Kari E.}",
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Justice, AE, Howard, AG, Chittoor, G, Fernandez-Rhodes, L, Graff, M, Voruganti, VS, Diao, G, Love, SAM, Franceschini, N, O'Connell, JR, Avery, CL, Young, KL & North, KE 2016, 'Genome-wide association of trajectories of systolic blood pressure change', BMC Proceedings, vol. 10, 56. https://doi.org/10.1186/s12919-016-0050-9

Genome-wide association of trajectories of systolic blood pressure change. / Justice, Anne E.; Howard, Annie Green; Chittoor, Geetha; Fernandez-Rhodes, Lindsay; Graff, Misa; Voruganti, V. Saroja; Diao, Guoqing; Love, Shelly Ann M.; Franceschini, Nora; O'Connell, Jeffrey R.; Avery, Christy L.; Young, Kristin L.; North, Kari E.

In: BMC Proceedings, Vol. 10, 56, 01.01.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide association of trajectories of systolic blood pressure change

AU - Justice, Anne E.

AU - Howard, Annie Green

AU - Chittoor, Geetha

AU - Fernandez-Rhodes, Lindsay

AU - Graff, Misa

AU - Voruganti, V. Saroja

AU - Diao, Guoqing

AU - Love, Shelly Ann M.

AU - Franceschini, Nora

AU - O'Connell, Jeffrey R.

AU - Avery, Christy L.

AU - Young, Kristin L.

AU - North, Kari E.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: There is great interindividual variation in systolic blood pressure (SBP) as a result of the influences of several factors, including sex, ancestry, smoking status, medication use, and, especially, age. The majority of genetic studies have examined SBP measured cross-sectionally; however, SBP changes over time, and not necessarily in a linear fashion. Therefore, this study conducted a genome-wide association (GWA) study of SBP change trajectories using data available through the Genetic Analysis Workshop 19 (GAW19) of 959 individuals from 20 extended Mexican American families from the San Antonio Family Studies with up to 4 measures of SBP. We performed structural equation modeling (SEM) while taking into account potential genetic effects to identify how, if at all, to include covariates in estimating the SBP change trajectories using a mixture model based latent class growth modeling (LCGM) approach for use in the GWA analyses. Results: The semiparametric LCGM approach identified 5 trajectory classes that captured SBP changes across age. Each LCGM identified trajectory group was ranked based on the average number of cumulative years as hypertensive. Using a pairwise comparison of these classes the heritability estimates range from 12 to 94 % (SE = 17 to 40 %). Conclusion: These identified trajectories are significantly heritable, and we identified a total of 8 promising loci that influence one's trajectory in SBP change across age. Our results demonstrate the potential utility of capitalizing on extant genetic data and longitudinal SBP assessments available through GAW19 to explore novel analytical methods with promising results.

AB - Background: There is great interindividual variation in systolic blood pressure (SBP) as a result of the influences of several factors, including sex, ancestry, smoking status, medication use, and, especially, age. The majority of genetic studies have examined SBP measured cross-sectionally; however, SBP changes over time, and not necessarily in a linear fashion. Therefore, this study conducted a genome-wide association (GWA) study of SBP change trajectories using data available through the Genetic Analysis Workshop 19 (GAW19) of 959 individuals from 20 extended Mexican American families from the San Antonio Family Studies with up to 4 measures of SBP. We performed structural equation modeling (SEM) while taking into account potential genetic effects to identify how, if at all, to include covariates in estimating the SBP change trajectories using a mixture model based latent class growth modeling (LCGM) approach for use in the GWA analyses. Results: The semiparametric LCGM approach identified 5 trajectory classes that captured SBP changes across age. Each LCGM identified trajectory group was ranked based on the average number of cumulative years as hypertensive. Using a pairwise comparison of these classes the heritability estimates range from 12 to 94 % (SE = 17 to 40 %). Conclusion: These identified trajectories are significantly heritable, and we identified a total of 8 promising loci that influence one's trajectory in SBP change across age. Our results demonstrate the potential utility of capitalizing on extant genetic data and longitudinal SBP assessments available through GAW19 to explore novel analytical methods with promising results.

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