Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants

Sinead Kelly, Derek W. Morris, Omar Mothersill, Emma Jane Rose, Ciara Fahey, Carol O'Brien, Erik O'Hanlon, Michael Gill, Aiden P. Corvin, Gary Donohoe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A single nucleotide polymorphism (SNP rs1625579) within the micro-RNA 137 (MIR137) gene recently achieved strong genome-wide association with schizophrenia (SZ). However, the mechanisms by which SZ risk may be mediated by this variant are unknown. As miRNAs have the potential to influence oligodendrocyte development, we investigated whether this SNP was associated with variability in white matter (WM) microstructure. Diffusion tensor imaging (DTI) was conducted on 123 healthy participants genotyped for rs1625579. The analysis consisted of whole-brain tract-based spatial statistics and atlas-based tractography analysis of six major WM tracts known to be affected in SZ - the inferior longitudinal fasciculus, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the anterior thalamic radiation, the cingulum bundle and the corpus callosum. No significant differences in either whole-brain fractional anisotropy or mean diffusivity between MIR137 genotype groups were observed (p>. 0.05). Similarly, atlas-based tractography of particular tracts implicated in SZ failed to reveal any significant differences between MIR137 genotype groups on measures of WM connectivity (p>. 0.05). In the absence of WM effects comparable to those reported for other SZ associated genes, these data suggest that MIR137 alone may not confer variability in these WM measures and therefore may not act in isolation for any effects that the variant may have on WM microstructure in SZ samples.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalNeuroscience letters
Volume574
DOIs
StatePublished - Jun 27 2014

Fingerprint

MicroRNAs
Schizophrenia
Healthy Volunteers
Genome
Single Nucleotide Polymorphism
Atlases
Genotype
Subthalamus
Diffusion Tensor Imaging
Corpus Callosum
Anisotropy
Oligodendroglia
Brain
Genes
White Matter
Radiation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kelly, Sinead ; Morris, Derek W. ; Mothersill, Omar ; Rose, Emma Jane ; Fahey, Ciara ; O'Brien, Carol ; O'Hanlon, Erik ; Gill, Michael ; Corvin, Aiden P. ; Donohoe, Gary. / Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants. In: Neuroscience letters. 2014 ; Vol. 574. pp. 6-10.
@article{e405e4fd2ab54a00bcf356e5c4bf32f6,
title = "Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants",
abstract = "A single nucleotide polymorphism (SNP rs1625579) within the micro-RNA 137 (MIR137) gene recently achieved strong genome-wide association with schizophrenia (SZ). However, the mechanisms by which SZ risk may be mediated by this variant are unknown. As miRNAs have the potential to influence oligodendrocyte development, we investigated whether this SNP was associated with variability in white matter (WM) microstructure. Diffusion tensor imaging (DTI) was conducted on 123 healthy participants genotyped for rs1625579. The analysis consisted of whole-brain tract-based spatial statistics and atlas-based tractography analysis of six major WM tracts known to be affected in SZ - the inferior longitudinal fasciculus, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the anterior thalamic radiation, the cingulum bundle and the corpus callosum. No significant differences in either whole-brain fractional anisotropy or mean diffusivity between MIR137 genotype groups were observed (p>. 0.05). Similarly, atlas-based tractography of particular tracts implicated in SZ failed to reveal any significant differences between MIR137 genotype groups on measures of WM connectivity (p>. 0.05). In the absence of WM effects comparable to those reported for other SZ associated genes, these data suggest that MIR137 alone may not confer variability in these WM measures and therefore may not act in isolation for any effects that the variant may have on WM microstructure in SZ samples.",
author = "Sinead Kelly and Morris, {Derek W.} and Omar Mothersill and Rose, {Emma Jane} and Ciara Fahey and Carol O'Brien and Erik O'Hanlon and Michael Gill and Corvin, {Aiden P.} and Gary Donohoe",
year = "2014",
month = "6",
day = "27",
doi = "10.1016/j.neulet.2014.05.002",
language = "English (US)",
volume = "574",
pages = "6--10",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

Kelly, S, Morris, DW, Mothersill, O, Rose, EJ, Fahey, C, O'Brien, C, O'Hanlon, E, Gill, M, Corvin, AP & Donohoe, G 2014, 'Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants', Neuroscience letters, vol. 574, pp. 6-10. https://doi.org/10.1016/j.neulet.2014.05.002

Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants. / Kelly, Sinead; Morris, Derek W.; Mothersill, Omar; Rose, Emma Jane; Fahey, Ciara; O'Brien, Carol; O'Hanlon, Erik; Gill, Michael; Corvin, Aiden P.; Donohoe, Gary.

In: Neuroscience letters, Vol. 574, 27.06.2014, p. 6-10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants

AU - Kelly, Sinead

AU - Morris, Derek W.

AU - Mothersill, Omar

AU - Rose, Emma Jane

AU - Fahey, Ciara

AU - O'Brien, Carol

AU - O'Hanlon, Erik

AU - Gill, Michael

AU - Corvin, Aiden P.

AU - Donohoe, Gary

PY - 2014/6/27

Y1 - 2014/6/27

N2 - A single nucleotide polymorphism (SNP rs1625579) within the micro-RNA 137 (MIR137) gene recently achieved strong genome-wide association with schizophrenia (SZ). However, the mechanisms by which SZ risk may be mediated by this variant are unknown. As miRNAs have the potential to influence oligodendrocyte development, we investigated whether this SNP was associated with variability in white matter (WM) microstructure. Diffusion tensor imaging (DTI) was conducted on 123 healthy participants genotyped for rs1625579. The analysis consisted of whole-brain tract-based spatial statistics and atlas-based tractography analysis of six major WM tracts known to be affected in SZ - the inferior longitudinal fasciculus, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the anterior thalamic radiation, the cingulum bundle and the corpus callosum. No significant differences in either whole-brain fractional anisotropy or mean diffusivity between MIR137 genotype groups were observed (p>. 0.05). Similarly, atlas-based tractography of particular tracts implicated in SZ failed to reveal any significant differences between MIR137 genotype groups on measures of WM connectivity (p>. 0.05). In the absence of WM effects comparable to those reported for other SZ associated genes, these data suggest that MIR137 alone may not confer variability in these WM measures and therefore may not act in isolation for any effects that the variant may have on WM microstructure in SZ samples.

AB - A single nucleotide polymorphism (SNP rs1625579) within the micro-RNA 137 (MIR137) gene recently achieved strong genome-wide association with schizophrenia (SZ). However, the mechanisms by which SZ risk may be mediated by this variant are unknown. As miRNAs have the potential to influence oligodendrocyte development, we investigated whether this SNP was associated with variability in white matter (WM) microstructure. Diffusion tensor imaging (DTI) was conducted on 123 healthy participants genotyped for rs1625579. The analysis consisted of whole-brain tract-based spatial statistics and atlas-based tractography analysis of six major WM tracts known to be affected in SZ - the inferior longitudinal fasciculus, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the anterior thalamic radiation, the cingulum bundle and the corpus callosum. No significant differences in either whole-brain fractional anisotropy or mean diffusivity between MIR137 genotype groups were observed (p>. 0.05). Similarly, atlas-based tractography of particular tracts implicated in SZ failed to reveal any significant differences between MIR137 genotype groups on measures of WM connectivity (p>. 0.05). In the absence of WM effects comparable to those reported for other SZ associated genes, these data suggest that MIR137 alone may not confer variability in these WM measures and therefore may not act in isolation for any effects that the variant may have on WM microstructure in SZ samples.

UR - http://www.scopus.com/inward/record.url?scp=84901617924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901617924&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2014.05.002

DO - 10.1016/j.neulet.2014.05.002

M3 - Article

VL - 574

SP - 6

EP - 10

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -