Genomic comparison of Mycobacterium avium subsp. paratuberculosis sheep and cattle strains by microarray hybridization

Ian B. Marsh, John P. Bannantine, Michael L. Paustian, Mark L. Tizard, Vivek Kapur, Richard J. Whittington

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65 Scopus citations

Abstract

Microarray-based comparisons of three Mycobacterium avium subsp. paratuberculosis isolates, including one sheep strain and two cattle strains, identified three large genomic deletions in the sheep strain, totaling 29,208 bp and involving 24 open reading frames. These deletions may help explain some of the differences in pathogenicity and host specificity observed between the cattle and sheep strains of Mycobacterium avium subsp. paratuberculosis.

Original languageEnglish (US)
Pages (from-to)2290-2293
Number of pages4
JournalJournal of bacteriology
Volume188
Issue number6
DOIs
StatePublished - Mar 1 2006

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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