Genomic comparison of Mycobacterium avium subsp. paratuberculosis sheep and cattle strains by microarray hybridization

Ian B. Marsh, John P. Bannantine, Michael L. Paustian, Mark L. Tizard, Vivek Kapur, Richard J. Whittington

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Microarray-based comparisons of three Mycobacterium avium subsp. paratuberculosis isolates, including one sheep strain and two cattle strains, identified three large genomic deletions in the sheep strain, totaling 29,208 bp and involving 24 open reading frames. These deletions may help explain some of the differences in pathogenicity and host specificity observed between the cattle and sheep strains of Mycobacterium avium subsp. paratuberculosis.

Original languageEnglish (US)
Pages (from-to)2290-2293
Number of pages4
JournalJournal of bacteriology
Volume188
Issue number6
DOIs
StatePublished - Mar 1 2006

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Paratuberculosis
Mycobacterium avium
Sheep
Host Specificity
Open Reading Frames
Virulence

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

Cite this

Marsh, Ian B. ; Bannantine, John P. ; Paustian, Michael L. ; Tizard, Mark L. ; Kapur, Vivek ; Whittington, Richard J. / Genomic comparison of Mycobacterium avium subsp. paratuberculosis sheep and cattle strains by microarray hybridization. In: Journal of bacteriology. 2006 ; Vol. 188, No. 6. pp. 2290-2293.
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Genomic comparison of Mycobacterium avium subsp. paratuberculosis sheep and cattle strains by microarray hybridization. / Marsh, Ian B.; Bannantine, John P.; Paustian, Michael L.; Tizard, Mark L.; Kapur, Vivek; Whittington, Richard J.

In: Journal of bacteriology, Vol. 188, No. 6, 01.03.2006, p. 2290-2293.

Research output: Contribution to journalArticle

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