Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

David J. Galgoczy, Ann Cassidy-Stone, Manuel Llinás, Sean M. O'Rourke, Ira Herskowitz, Joseph L. DeRisi, Alexander D. Johnson

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The budding yeast Saccharomyces cerevisiae has three cell types (a cells, a cells, and a/a cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.

Original languageEnglish (US)
Pages (from-to)18069-18074
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number52
DOIs
StatePublished - Dec 28 2004

All Science Journal Classification (ASJC) codes

  • General

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