Genomic encyclopedia of type strains of the genus Bifidobacterium

Christian Milani, Gabriele Andrea Lugli, Sabrina Duranti, Francesca Turroni, Francesca Bottacini, Marta Mangifesta, Borja Sanchez, Alice Viappiani, Leonardo Mancabelli, Bernard Taminiau, Véronique Delcenserie, Rodolphe Barrangou, Abelardo Margolles, Douwe van Sinderen, Marco Ventura

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Bifidobacteria represent one of the dominant microbial groups that are present in the gut of various animals, being particularly prevalent during the suckling stage of life of humans and other mammals. However, the overall genome structure of this group of microorganisms remains largely unexplored. Here, we sequenced the genomes of 42 representative (sub)species across the Bifidobacterium genus and used this information to explore the overall genetic picture of this bacterial group. Furthermore, the genomic data described here were used to reconstruct the evolutionary development of the Bifidobacterium genus. This reconstruction suggests that its evolution was substantially influenced by genetic adaptations to obtain access to glycans, thereby representing a common and potent evolutionary force in shaping bifidobacterial genomes.

Original languageEnglish (US)
Pages (from-to)6290-6302
Number of pages13
JournalApplied and environmental microbiology
Volume80
Issue number20
DOIs
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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