Genomic evidence for the Pleistocene and recent population history of Native Americans

Maanasa Raghavan, Matthias Steinrücken, Kelley Harris, Stephan Schiffels, Simon Rasmussen, Michael DeGiorgio, Anders Albrechtsen, Cristina Valdiosera, María C. Ávila-Arcos, Anna Sapfo Malaspinas, Anders Eriksson, Ida Moltke, Mait Metspalu, Julian R. Homburger, Jeff Wall, Omar E. Cornejo, J. Víctor Moreno-Mayar, Thorfinn S. Korneliussen, Tracey Pierre, Morten RasmussenPaula F. Campos, Peter De Barros Damgaard, Morten E. Allentoft, John Lindo, Ene Metspalu, Ricardo Rodríguez-Varela, Josefina Mansilla, Celeste Henrickson, Andaine Seguin-Orlando, Helena Malmstöm, Thomas Stafford, Suyash S. Shringarpure, Andrés Moreno-Estrada, Monika Karmin, Kristiina Tambets, Anders Bergström, Yali Xue, Vera Warmuth, Andrew D. Friend, Joy Singarayer, Paul Valdes, Francois Balloux, Ilán Leboreiro, Jose Luis Vera, Hector Rangel-Villalobos, Davide Pettener, Donata Luiselli, Loren G. Davis, Evelyne Heyer, Christoph P.E. Zollikofer, Marcia S. Ponce De León, Colin I. Smith, Vaughan Grimes, Kelly Anne Pike, Michael Deal, Benjamin T. Fuller, Bernardo Arriaza, Vivien Standen, Maria F. Luz, Francois Ricaut, Niede Guidon, Ludmila Osipova, Mikhail I. Voevoda, Olga L. Posukh, Oleg Balanovsky, Maria Lavryashina, Yuri Bogunov, Elza Khusnutdinova, Marina Gubina, Elena Balanovska, Sardana Fedorova, Sergey Litvinov, Boris Malyarchuk, Miroslava Derenko, M. J. Mosher, David Archer, Jerome Cybulski, Barbara Petzelt, Joycelynn Mitchell, Rosita Worl, Paul J. Norman, Peter Parham, Brian M. Kemp, Toomas Kivisild, Chris Tyler-Smith, Manjinder S. Sandhu, Michael Crawford, Richard Villems, David Glenn Smith, Michael R. Waters, Ted Goebel, John R. Johnson, Ripan S. Malhi, Mattias Jakobsson, David J. Meltzer, Andrea Manica, Richard Durbin, Carlos D. Bustamante, Yun S. Song, Rasmus Nielsen, Eske Willerslev

Research output: Contribution to journalArticlepeer-review

218 Scopus citations

Abstract

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.

Original languageEnglish (US)
Article numberaab3884
JournalScience
Volume349
Issue number6250
DOIs
StatePublished - Aug 21 2015

All Science Journal Classification (ASJC) codes

  • General

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