Germline Stem Cells

Ji Wu, Huacheng Luo, Hu Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Stem cells support tissue maintenance by balancing self-renewal and differentiation. Germline stem cells (GSCs) belong to a kind of stem cells that are crucial to development and tissue homeostasis with their ability to both differentiate into gametes and maintain an undifferentiated state by their self-renewal property. The GSCs are unique in that they transmit genetic information from parent to offspring. In this review, we concentrate on human and mammalian models including rat and mouse, which are used to study GSCs, and summarize current progress about the GSC origin, location, characteristics, regulatory mechanisms, application, and role of GSCs in gametogenesis.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages97-126
Number of pages30
DOIs
StatePublished - 2013

Publication series

NameCurrent Topics in Developmental Biology
Volume102
ISSN (Print)0070-2153

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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    Wu, J., Luo, H., & Wang, H. (2013). Germline Stem Cells. In Current Topics in Developmental Biology (pp. 97-126). (Current Topics in Developmental Biology; Vol. 102). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-416024-8.00004-0