Gestational weight gain in women with polycystic ovary syndrome: A controlled study

James Kent, William Dodson, Allen Kunselman, Jaimey Pauli, Alicia Stone, Michael P. Diamond, Christos Coutifaris, William D. Schlaff, Ruben Alvero, Peter Casson, Gregory M. Christman, R. Mitchell Rosen, Karl R. Hansen, Randall D. Robinson, Valerie Baker, Rebecca Usadi, Nanette Santoro, Heping Zhang, Esther Eisenberg, Richard Legro

Research output: Contribution to journalArticle

Abstract

Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.

Original languageEnglish (US)
Pages (from-to)4315-4323
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume103
Issue number11
DOIs
StatePublished - Jan 1 2018

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Polycystic Ovary Syndrome
Weight Gain
Weights and Measures
Body Mass Index
Pregnancy Complications
Second Pregnancy Trimester
Obesity
Pregnancy
Medical problems
Gestational Diabetes
First Pregnancy Trimester
Pre-Eclampsia
Infertility
Cohort Studies
Research Design
Outcome Assessment (Health Care)
Prospective Studies
Control Groups

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kent, James ; Dodson, William ; Kunselman, Allen ; Pauli, Jaimey ; Stone, Alicia ; Diamond, Michael P. ; Coutifaris, Christos ; Schlaff, William D. ; Alvero, Ruben ; Casson, Peter ; Christman, Gregory M. ; Rosen, R. Mitchell ; Hansen, Karl R. ; Robinson, Randall D. ; Baker, Valerie ; Usadi, Rebecca ; Santoro, Nanette ; Zhang, Heping ; Eisenberg, Esther ; Legro, Richard. / Gestational weight gain in women with polycystic ovary syndrome : A controlled study. In: Journal of Clinical Endocrinology and Metabolism. 2018 ; Vol. 103, No. 11. pp. 4315-4323.
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title = "Gestational weight gain in women with polycystic ovary syndrome: A controlled study",
abstract = "Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95{\%} CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95{\%} CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95{\%} CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95{\%} CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.",
author = "James Kent and William Dodson and Allen Kunselman and Jaimey Pauli and Alicia Stone and Diamond, {Michael P.} and Christos Coutifaris and Schlaff, {William D.} and Ruben Alvero and Peter Casson and Christman, {Gregory M.} and Rosen, {R. Mitchell} and Hansen, {Karl R.} and Robinson, {Randall D.} and Valerie Baker and Rebecca Usadi and Nanette Santoro and Heping Zhang and Esther Eisenberg and Richard Legro",
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Kent, J, Dodson, W, Kunselman, A, Pauli, J, Stone, A, Diamond, MP, Coutifaris, C, Schlaff, WD, Alvero, R, Casson, P, Christman, GM, Rosen, RM, Hansen, KR, Robinson, RD, Baker, V, Usadi, R, Santoro, N, Zhang, H, Eisenberg, E & Legro, R 2018, 'Gestational weight gain in women with polycystic ovary syndrome: A controlled study', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 11, pp. 4315-4323. https://doi.org/10.1210/jc.2017-02764

Gestational weight gain in women with polycystic ovary syndrome : A controlled study. / Kent, James; Dodson, William; Kunselman, Allen; Pauli, Jaimey; Stone, Alicia; Diamond, Michael P.; Coutifaris, Christos; Schlaff, William D.; Alvero, Ruben; Casson, Peter; Christman, Gregory M.; Rosen, R. Mitchell; Hansen, Karl R.; Robinson, Randall D.; Baker, Valerie; Usadi, Rebecca; Santoro, Nanette; Zhang, Heping; Eisenberg, Esther; Legro, Richard.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 103, No. 11, 01.01.2018, p. 4315-4323.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gestational weight gain in women with polycystic ovary syndrome

T2 - A controlled study

AU - Kent, James

AU - Dodson, William

AU - Kunselman, Allen

AU - Pauli, Jaimey

AU - Stone, Alicia

AU - Diamond, Michael P.

AU - Coutifaris, Christos

AU - Schlaff, William D.

AU - Alvero, Ruben

AU - Casson, Peter

AU - Christman, Gregory M.

AU - Rosen, R. Mitchell

AU - Hansen, Karl R.

AU - Robinson, Randall D.

AU - Baker, Valerie

AU - Usadi, Rebecca

AU - Santoro, Nanette

AU - Zhang, Heping

AU - Eisenberg, Esther

AU - Legro, Richard

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.

AB - Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.

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