Ghrelin and food reward: The story of potential underlying substrates

Karolina P. Skibicka, Suzanne L. Dickson

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

The incidence of obesity is increasing at an alarming rate and this worldwide epidemic represents a significant decrease in life span and quality of life of a large part of the affected population. Therefore an understanding of mechanisms underlying food overconsumption and obesity development is urgent and essential to find potential treatments. Research investigating mechanisms underlying obesity and the control of food intake has recently experienced a major shift in focus, from the brain's hypothalamus to additional important neural circuits controlling emotion, cognition and motivated behavior. Among them, the mesolimbic system, and the changes in reward and motivated behavior for food, emerge as new promising treatment targets. Furthermore, there is also growing appreciation of the impact of peripheral hormones that signal nutrition status to the mesolimbic areas, and especially the only known circulating orexigenic hormone, ghrelin. This review article provides a synthesis of recent evidence concerning the impact of manipulation of ghrelin and its receptor on models of food reward/food motivation behavior and the mesolimbic circuitry. Particular attention is given to the potential neurocircuitry and neurotransmitter systems downstream of ghrelin's effects on food reward.

Original languageEnglish (US)
Pages (from-to)2265-2273
Number of pages9
JournalPeptides
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2011

Fingerprint

Ghrelin
Reward
Food
Substrates
Obesity
Quality of Life
Ghrelin Receptor
Hormones
Nutritional Status
Cognition
Hypothalamus
Neurotransmitter Agents
Motivation
Nutrition
Emotions
Eating
Brain
Incidence
Research
Networks (circuits)

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Skibicka, Karolina P. ; Dickson, Suzanne L. / Ghrelin and food reward : The story of potential underlying substrates. In: Peptides. 2011 ; Vol. 32, No. 11. pp. 2265-2273.
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Ghrelin and food reward : The story of potential underlying substrates. / Skibicka, Karolina P.; Dickson, Suzanne L.

In: Peptides, Vol. 32, No. 11, 01.11.2011, p. 2265-2273.

Research output: Contribution to journalReview article

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AB - The incidence of obesity is increasing at an alarming rate and this worldwide epidemic represents a significant decrease in life span and quality of life of a large part of the affected population. Therefore an understanding of mechanisms underlying food overconsumption and obesity development is urgent and essential to find potential treatments. Research investigating mechanisms underlying obesity and the control of food intake has recently experienced a major shift in focus, from the brain's hypothalamus to additional important neural circuits controlling emotion, cognition and motivated behavior. Among them, the mesolimbic system, and the changes in reward and motivated behavior for food, emerge as new promising treatment targets. Furthermore, there is also growing appreciation of the impact of peripheral hormones that signal nutrition status to the mesolimbic areas, and especially the only known circulating orexigenic hormone, ghrelin. This review article provides a synthesis of recent evidence concerning the impact of manipulation of ghrelin and its receptor on models of food reward/food motivation behavior and the mesolimbic circuitry. Particular attention is given to the potential neurocircuitry and neurotransmitter systems downstream of ghrelin's effects on food reward.

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