Ghrelin but not peptide yy is related to change in body weight and energy availability

Jennifer L. Scheid, Mary Jane De Souza, Heather J. Leidy, Nancy Williams

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: The aim of this study was to examine changes in fasting total peptide YY (PYY) and ghrelin in nonobese premenopausal women after an exercise and diet program with and without weight loss. Methods: Body composition, energy balance parameters, ghrelin, and PYY were measured before and after a 3-month intervention in nonexercising controls (n = 7) and exercising women who either remained weight stable (n = 5) or lost weight (n = 10). At baseline, subjects were 20.6 ± 2.2 yr, weighed 58.0 ± 4.8 kg, and had 27.2% ± 4.9% body fat. Supervised exercise training occurred five times a week for up to 90 min at 70%-80% of maximum HR. Subjects were fed a controlled diet. Results: Body weight (-3.2 ± 0.8 kg) and fat mass (-2.6 ± 0.7 kg) decreased significantly in the weight-loss exercise group. Neither fasting ghrelin nor PYY changed in response to exercise training in the absence of weight loss, and PYY did not change with exercise and weight loss. Fasting ghrelin did reveal a significant time × experimental group interaction (P = 0.025). The change in ghrelin was inversely correlated with the change in body weight, body mass index, fat-free mass, and energy availability. Conclusions: Neither fasting ghrelin nor fasting PYY seem to play a role in the adaptive changes associated with exercise training when exercise occurs in the absence of weight loss. Fasting ghrelin concentrations increase when body weight is lost and may respond to even smaller changes in energy availability. However, fasting PYY does not seem to play a key role in the regulation of energy balance during diet-and exercise-associated weight loss.

Original languageEnglish (US)
Pages (from-to)2063-2071
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume43
Issue number11
DOIs
StatePublished - Jan 1 2011

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Body Weight Changes
Ghrelin
Peptide YY
Fasting
Exercise
Weight Loss
Peptides
Diet
Fats
Body Weight
Weights and Measures
Body Composition
Adipose Tissue
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

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title = "Ghrelin but not peptide yy is related to change in body weight and energy availability",
abstract = "Purpose: The aim of this study was to examine changes in fasting total peptide YY (PYY) and ghrelin in nonobese premenopausal women after an exercise and diet program with and without weight loss. Methods: Body composition, energy balance parameters, ghrelin, and PYY were measured before and after a 3-month intervention in nonexercising controls (n = 7) and exercising women who either remained weight stable (n = 5) or lost weight (n = 10). At baseline, subjects were 20.6 ± 2.2 yr, weighed 58.0 ± 4.8 kg, and had 27.2{\%} ± 4.9{\%} body fat. Supervised exercise training occurred five times a week for up to 90 min at 70{\%}-80{\%} of maximum HR. Subjects were fed a controlled diet. Results: Body weight (-3.2 ± 0.8 kg) and fat mass (-2.6 ± 0.7 kg) decreased significantly in the weight-loss exercise group. Neither fasting ghrelin nor PYY changed in response to exercise training in the absence of weight loss, and PYY did not change with exercise and weight loss. Fasting ghrelin did reveal a significant time × experimental group interaction (P = 0.025). The change in ghrelin was inversely correlated with the change in body weight, body mass index, fat-free mass, and energy availability. Conclusions: Neither fasting ghrelin nor fasting PYY seem to play a role in the adaptive changes associated with exercise training when exercise occurs in the absence of weight loss. Fasting ghrelin concentrations increase when body weight is lost and may respond to even smaller changes in energy availability. However, fasting PYY does not seem to play a key role in the regulation of energy balance during diet-and exercise-associated weight loss.",
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Ghrelin but not peptide yy is related to change in body weight and energy availability. / Scheid, Jennifer L.; De Souza, Mary Jane; Leidy, Heather J.; Williams, Nancy.

In: Medicine and Science in Sports and Exercise, Vol. 43, No. 11, 01.01.2011, p. 2063-2071.

Research output: Contribution to journalArticle

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