Ghrelin increases intake of rewarding food in rodents

Emil Egecioglu, Elisabet Jerlhag, Nicolas Salomé, Karolina Skibicka, David Haage, Mohammad Bohlooly-Y, Daniel Andersson, Mikael Bjursell, Daniel Perrissoud, Jörgen A. Engel, Suzanne L. Dickson

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalAddiction Biology
Volume15
Issue number3
DOIs
StatePublished - Jan 1 2010

Fingerprint

Ghrelin
Ghrelin Receptor
Rodentia
Eating
Ventral Tegmental Area
Food
Aptitude
Reward
Knockout Mice
Motivation
Dopamine
Genes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

Cite this

Egecioglu, E., Jerlhag, E., Salomé, N., Skibicka, K., Haage, D., Bohlooly-Y, M., ... Dickson, S. L. (2010). Ghrelin increases intake of rewarding food in rodents. Addiction Biology, 15(3), 304-311. https://doi.org/10.1111/j.1369-1600.2010.00216.x
Egecioglu, Emil ; Jerlhag, Elisabet ; Salomé, Nicolas ; Skibicka, Karolina ; Haage, David ; Bohlooly-Y, Mohammad ; Andersson, Daniel ; Bjursell, Mikael ; Perrissoud, Daniel ; Engel, Jörgen A. ; Dickson, Suzanne L. / Ghrelin increases intake of rewarding food in rodents. In: Addiction Biology. 2010 ; Vol. 15, No. 3. pp. 304-311.
@article{f8c0974cf17c4894acbb3b5ff5eb40ac,
title = "Ghrelin increases intake of rewarding food in rodents",
abstract = "We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.",
author = "Emil Egecioglu and Elisabet Jerlhag and Nicolas Salom{\'e} and Karolina Skibicka and David Haage and Mohammad Bohlooly-Y and Daniel Andersson and Mikael Bjursell and Daniel Perrissoud and Engel, {J{\"o}rgen A.} and Dickson, {Suzanne L.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1111/j.1369-1600.2010.00216.x",
language = "English (US)",
volume = "15",
pages = "304--311",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "3",

}

Egecioglu, E, Jerlhag, E, Salomé, N, Skibicka, K, Haage, D, Bohlooly-Y, M, Andersson, D, Bjursell, M, Perrissoud, D, Engel, JA & Dickson, SL 2010, 'Ghrelin increases intake of rewarding food in rodents', Addiction Biology, vol. 15, no. 3, pp. 304-311. https://doi.org/10.1111/j.1369-1600.2010.00216.x

Ghrelin increases intake of rewarding food in rodents. / Egecioglu, Emil; Jerlhag, Elisabet; Salomé, Nicolas; Skibicka, Karolina; Haage, David; Bohlooly-Y, Mohammad; Andersson, Daniel; Bjursell, Mikael; Perrissoud, Daniel; Engel, Jörgen A.; Dickson, Suzanne L.

In: Addiction Biology, Vol. 15, No. 3, 01.01.2010, p. 304-311.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ghrelin increases intake of rewarding food in rodents

AU - Egecioglu, Emil

AU - Jerlhag, Elisabet

AU - Salomé, Nicolas

AU - Skibicka, Karolina

AU - Haage, David

AU - Bohlooly-Y, Mohammad

AU - Andersson, Daniel

AU - Bjursell, Mikael

AU - Perrissoud, Daniel

AU - Engel, Jörgen A.

AU - Dickson, Suzanne L.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

AB - We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

UR - http://www.scopus.com/inward/record.url?scp=77953194478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953194478&partnerID=8YFLogxK

U2 - 10.1111/j.1369-1600.2010.00216.x

DO - 10.1111/j.1369-1600.2010.00216.x

M3 - Article

C2 - 20477752

AN - SCOPUS:77953194478

VL - 15

SP - 304

EP - 311

JO - Addiction Biology

JF - Addiction Biology

SN - 1355-6215

IS - 3

ER -

Egecioglu E, Jerlhag E, Salomé N, Skibicka K, Haage D, Bohlooly-Y M et al. Ghrelin increases intake of rewarding food in rodents. Addiction Biology. 2010 Jan 1;15(3):304-311. https://doi.org/10.1111/j.1369-1600.2010.00216.x