Ghrelin increases intake of rewarding food in rodents

Emil Egecioglu, Elisabet Jerlhag, Nicolas Salomé, Karolina P. Skibicka, David Haage, Mohammad Bohlooly-Y, Daniel Andersson, Mikael Bjursell, Daniel Perrissoud, Jörgen A. Engel, Suzanne L. Dickson

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Abstract

We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalAddiction Biology
Volume15
Issue number3
DOIs
StatePublished - Jul 2010

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

Cite this

Egecioglu, E., Jerlhag, E., Salomé, N., Skibicka, K. P., Haage, D., Bohlooly-Y, M., Andersson, D., Bjursell, M., Perrissoud, D., Engel, J. A., & Dickson, S. L. (2010). Ghrelin increases intake of rewarding food in rodents. Addiction Biology, 15(3), 304-311. https://doi.org/10.1111/j.1369-1600.2010.00216.x