Abstract
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 304-311 |
| Number of pages | 8 |
| Journal | Addiction Biology |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2010 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Pharmacology
- Psychiatry and Mental health
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Ghrelin increases intake of rewarding food in rodents. / Egecioglu, Emil; Jerlhag, Elisabet; Salomé, Nicolas; Skibicka, Karolina P.; Haage, David; Bohlooly-Y, Mohammad; Andersson, Daniel; Bjursell, Mikael; Perrissoud, Daniel; Engel, Jörgen A.; Dickson, Suzanne L.
In: Addiction Biology, Vol. 15, No. 3, 07.2010, p. 304-311.Research output: Contribution to journal › Article
TY - JOUR
T1 - Ghrelin increases intake of rewarding food in rodents
AU - Egecioglu, Emil
AU - Jerlhag, Elisabet
AU - Salomé, Nicolas
AU - Skibicka, Karolina P.
AU - Haage, David
AU - Bohlooly-Y, Mohammad
AU - Andersson, Daniel
AU - Bjursell, Mikael
AU - Perrissoud, Daniel
AU - Engel, Jörgen A.
AU - Dickson, Suzanne L.
PY - 2010/7
Y1 - 2010/7
N2 - We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.
AB - We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.
UR - http://www.scopus.com/inward/record.url?scp=77953194478&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953194478&partnerID=8YFLogxK
U2 - 10.1111/j.1369-1600.2010.00216.x
DO - 10.1111/j.1369-1600.2010.00216.x
M3 - Article
C2 - 20477752
AN - SCOPUS:77953194478
VL - 15
SP - 304
EP - 311
JO - Addiction Biology
JF - Addiction Biology
SN - 1355-6215
IS - 3
ER -