Ghrelin Influences Novelty Seeking Behavior in Rodents and Men

Caroline Hansson, Rozita H. Shirazi, Jakob Näslund, Heike Vogel, Corinna Neuber, Göran Holm, Henrik Anckarsäter, Suzanne L. Dickson, Elias Eriksson, Karolina P. Skibicka

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Recent discoveries indicate an important role for ghrelin in drug and alcohol reward and an ability of ghrelin to regulate mesolimbic dopamine activity. The role of dopamine in novelty seeking, and the association between this trait and drug and alcohol abuse, led us to hypothesize that ghrelin may influence novelty seeking behavior. To test this possibility we applied several complementary rodent models of novelty seeking behavior, i.e. inescapable novelty-induced locomotor activity (NILA), novelty-induced place preference and novel object exploration, in rats subjected to acute ghrelin receptor (growth hormone secretagogue receptor; GHSR) stimulation or blockade. Furthermore we assessed the possible association between polymorphisms in the genes encoding ghrelin and GHSR and novelty seeking behavior in humans. The rodent studies indicate an important role for ghrelin in a wide range of novelty seeking behaviors. Ghrelin-injected rats exhibited a higher preference for a novel environment and increased novel object exploration. Conversely, those with GHSR blockade drastically reduced their preference for a novel environment and displayed decreased NILA. Importantly, the mesolimbic ventral tegmental area selective GHSR blockade was sufficient to reduce the NILA response indicating that the mesolimbic GHSRs might play an important role in the observed novelty responses. Moreover, in untreated animals, a striking positive correlation between NILA and sucrose reward behavior was detected. Two GHSR single nucleotide polymorphisms (SNPs), rs2948694 and rs495225, were significantly associated with the personality trait novelty seeking, as assessed using the Temperament and Character Inventory (TCI), in human subjects. This study provides the first evidence for a role of ghrelin in novelty seeking behavior in animals and humans, and also points to an association between food reward and novelty seeking in rodents.

Original languageEnglish (US)
Article numbere50409
JournalPloS one
Volume7
Issue number12
DOIs
StatePublished - Dec 5 2012

Fingerprint

ghrelin
Exploratory Behavior
Ghrelin
Rodentia
rodents
Locomotion
locomotion
Reward
Ghrelin Receptor
human behavior
dopamine
Polymorphism
Rats
Dopamine
Animals
Alcohols
drug abuse
Ventral Tegmental Area
temperament
Gene encoding

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Hansson, C., Shirazi, R. H., Näslund, J., Vogel, H., Neuber, C., Holm, G., ... Skibicka, K. P. (2012). Ghrelin Influences Novelty Seeking Behavior in Rodents and Men. PloS one, 7(12), [e50409]. https://doi.org/10.1371/journal.pone.0050409
Hansson, Caroline ; Shirazi, Rozita H. ; Näslund, Jakob ; Vogel, Heike ; Neuber, Corinna ; Holm, Göran ; Anckarsäter, Henrik ; Dickson, Suzanne L. ; Eriksson, Elias ; Skibicka, Karolina P. / Ghrelin Influences Novelty Seeking Behavior in Rodents and Men. In: PloS one. 2012 ; Vol. 7, No. 12.
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Hansson, C, Shirazi, RH, Näslund, J, Vogel, H, Neuber, C, Holm, G, Anckarsäter, H, Dickson, SL, Eriksson, E & Skibicka, KP 2012, 'Ghrelin Influences Novelty Seeking Behavior in Rodents and Men', PloS one, vol. 7, no. 12, e50409. https://doi.org/10.1371/journal.pone.0050409

Ghrelin Influences Novelty Seeking Behavior in Rodents and Men. / Hansson, Caroline; Shirazi, Rozita H.; Näslund, Jakob; Vogel, Heike; Neuber, Corinna; Holm, Göran; Anckarsäter, Henrik; Dickson, Suzanne L.; Eriksson, Elias; Skibicka, Karolina P.

In: PloS one, Vol. 7, No. 12, e50409, 05.12.2012.

Research output: Contribution to journalArticle

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Hansson C, Shirazi RH, Näslund J, Vogel H, Neuber C, Holm G et al. Ghrelin Influences Novelty Seeking Behavior in Rodents and Men. PloS one. 2012 Dec 5;7(12). e50409. https://doi.org/10.1371/journal.pone.0050409