Glioblastoma stem-like cells-biology and therapeutic implications

Demirkan B. Gürsel, Benjamin J. Shin, Jan Karl Burkhardt, Kartik Kesavabhotla, Cody D. Schlaff, John A. Boockvar

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.

Original languageEnglish (US)
Pages (from-to)2655-2666
Number of pages12
JournalCancers
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2011

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Neoplastic Stem Cells
Glioblastoma
Cell Biology
Stem Cells
Therapeutics
Maintenance
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Gürsel, D. B., Shin, B. J., Burkhardt, J. K., Kesavabhotla, K., Schlaff, C. D., & Boockvar, J. A. (2011). Glioblastoma stem-like cells-biology and therapeutic implications. Cancers, 3(2), 2655-2666. https://doi.org/10.3390/cancers3022655
Gürsel, Demirkan B. ; Shin, Benjamin J. ; Burkhardt, Jan Karl ; Kesavabhotla, Kartik ; Schlaff, Cody D. ; Boockvar, John A. / Glioblastoma stem-like cells-biology and therapeutic implications. In: Cancers. 2011 ; Vol. 3, No. 2. pp. 2655-2666.
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Gürsel, DB, Shin, BJ, Burkhardt, JK, Kesavabhotla, K, Schlaff, CD & Boockvar, JA 2011, 'Glioblastoma stem-like cells-biology and therapeutic implications', Cancers, vol. 3, no. 2, pp. 2655-2666. https://doi.org/10.3390/cancers3022655

Glioblastoma stem-like cells-biology and therapeutic implications. / Gürsel, Demirkan B.; Shin, Benjamin J.; Burkhardt, Jan Karl; Kesavabhotla, Kartik; Schlaff, Cody D.; Boockvar, John A.

In: Cancers, Vol. 3, No. 2, 01.06.2011, p. 2655-2666.

Research output: Contribution to journalReview article

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AU - Gürsel, Demirkan B.

AU - Shin, Benjamin J.

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AU - Boockvar, John A.

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AB - The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.

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Gürsel DB, Shin BJ, Burkhardt JK, Kesavabhotla K, Schlaff CD, Boockvar JA. Glioblastoma stem-like cells-biology and therapeutic implications. Cancers. 2011 Jun 1;3(2):2655-2666. https://doi.org/10.3390/cancers3022655