Abstract
Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1909-1912 |
| Number of pages | 4 |
| Journal | Journal of virology |
| Volume | 89 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2015 |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology
Cite this
}
Global displacement of canine parvovirus by a host-adapted variant : Structural comparison between pandemic viruses with distinct host ranges. / Organtini, Lindsey J.; Allison, Andrew B.; Lukk, Tiit; Parrish, Colin R.; Hafenstein, Susan.
In: Journal of virology, Vol. 89, No. 3, 01.01.2015, p. 1909-1912.Research output: Contribution to journal › Article
TY - JOUR
T1 - Global displacement of canine parvovirus by a host-adapted variant
T2 - Structural comparison between pandemic viruses with distinct host ranges
AU - Organtini, Lindsey J.
AU - Allison, Andrew B.
AU - Lukk, Tiit
AU - Parrish, Colin R.
AU - Hafenstein, Susan
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.
AB - Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.
UR - http://www.scopus.com/inward/record.url?scp=84921476216&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921476216&partnerID=8YFLogxK
U2 - 10.1128/JVI.02611-14
DO - 10.1128/JVI.02611-14
M3 - Article
C2 - 25410876
AN - SCOPUS:84921476216
VL - 89
SP - 1909
EP - 1912
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 3
ER -