Global displacement of canine parvovirus by a host-adapted variant: Structural comparison between pandemic viruses with distinct host ranges

Lindsey J. Organtini, Andrew B. Allison, Tiit Lukk, Colin R. Parrish, Susan Hafenstein

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

Original languageEnglish (US)
Pages (from-to)1909-1912
Number of pages4
JournalJournal of virology
Volume89
Issue number3
DOIs
StatePublished - Jan 1 2015

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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