Global displacement of canine parvovirus by a host-adapted variant: Structural comparison between pandemic viruses with distinct host ranges

Lindsey J. Organtini, Andrew B. Allison, Tiit Lukk, Colin R. Parrish, Susan Hafenstein

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

Original languageEnglish (US)
Pages (from-to)1909-1912
Number of pages4
JournalJournal of virology
Volume89
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Canine Parvovirus
Carnivore protoparvovirus 1
capsid
Capsid
Host Specificity
Pandemics
pandemic
host range
Viruses
mutation
viruses
Mutation
sialic acids
crystal structure
glycine (amino acid)
Glycine
hydrogen
Hydrogen
X-radiation
X-Rays

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Organtini, Lindsey J. ; Allison, Andrew B. ; Lukk, Tiit ; Parrish, Colin R. ; Hafenstein, Susan. / Global displacement of canine parvovirus by a host-adapted variant : Structural comparison between pandemic viruses with distinct host ranges. In: Journal of virology. 2015 ; Vol. 89, No. 3. pp. 1909-1912.
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Global displacement of canine parvovirus by a host-adapted variant : Structural comparison between pandemic viruses with distinct host ranges. / Organtini, Lindsey J.; Allison, Andrew B.; Lukk, Tiit; Parrish, Colin R.; Hafenstein, Susan.

In: Journal of virology, Vol. 89, No. 3, 01.01.2015, p. 1909-1912.

Research output: Contribution to journalArticle

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