Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training

Garrett I. Ash; Matthew A. Kostek; Harold Lee; Theodore J. Angelopoulos; Priscilla M. Clarkson; Paul M. Gordon; Niall M. Moyna; Paul S. Visich; Robert F. Zoeller; Thomas B. Price; Joseph M. Devaney; Heathe Gordish-Dressman; Paul D. Thompson; Eric P. Hoffman; Linda S. Pescatello

doi:10.1371/journal.pone.0148112

Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training

Garrett I. Ash, Matthew A. Kostek, Harold Lee, Theodore J. Angelopoulos, Priscilla M. Clarkson, Paul M. Gordon, Niall M. Moyna, Paul S. Visich, Robert F. Zoeller, Thomas B. Price, Joseph M. Devaney, Heathe Gordish-Dressman, Paul D. Thompson, Eric P. Hoffman, Linda S. Pescatello

Biobehavioral Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm²) preand post-resistance training. Subjects were genotyped for NR3C1-2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3 ±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes.We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol's actions in muscle tissue as they interact with sex differences in cortisol production.

Original language	English (US)
Article number	e0148112
Journal	PloS one
Volume	11
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0148112
State	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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Ash, G. I., Kostek, M. A., Lee, H., Angelopoulos, T. J., Clarkson, P. M., Gordon, P. M., Moyna, N. M., Visich, P. S., Zoeller, R. F., Price, T. B., Devaney, J. M., Gordish-Dressman, H., Thompson, P. D., Hoffman, E. P., & Pescatello, L. S. (2016). Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training. PloS one, 11(1), [e0148112]. https://doi.org/10.1371/journal.pone.0148112

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title = "Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training",

abstract = "Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) preand post-resistance training. Subjects were genotyped for NR3C1-2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3 ±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes.We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol's actions in muscle tissue as they interact with sex differences in cortisol production.",

author = "Ash, {Garrett I.} and Kostek, {Matthew A.} and Harold Lee and Angelopoulos, {Theodore J.} and Clarkson, {Priscilla M.} and Gordon, {Paul M.} and Moyna, {Niall M.} and Visich, {Paul S.} and Zoeller, {Robert F.} and Price, {Thomas B.} and Devaney, {Joseph M.} and Heathe Gordish-Dressman and Thompson, {Paul D.} and Hoffman, {Eric P.} and Pescatello, {Linda S.}",

note = "Publisher Copyright: {\textcopyright} 2016 Ash et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2016",

month = jan,

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Ash, GI, Kostek, MA, Lee, H, Angelopoulos, TJ, Clarkson, PM, Gordon, PM, Moyna, NM, Visich, PS, Zoeller, RF, Price, TB, Devaney, JM, Gordish-Dressman, H, Thompson, PD, Hoffman, EP & Pescatello, LS 2016, 'Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training', PloS one, vol. 11, no. 1, e0148112. https://doi.org/10.1371/journal.pone.0148112

TY - JOUR

T1 - Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training

AU - Ash, Garrett I.

AU - Kostek, Matthew A.

AU - Lee, Harold

AU - Angelopoulos, Theodore J.

AU - Clarkson, Priscilla M.

AU - Gordon, Paul M.

AU - Moyna, Niall M.

AU - Visich, Paul S.

AU - Zoeller, Robert F.

AU - Price, Thomas B.

AU - Devaney, Joseph M.

AU - Gordish-Dressman, Heathe

AU - Thompson, Paul D.

AU - Hoffman, Eric P.

AU - Pescatello, Linda S.

N1 - Publisher Copyright: © 2016 Ash et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) preand post-resistance training. Subjects were genotyped for NR3C1-2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3 ±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes.We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol's actions in muscle tissue as they interact with sex differences in cortisol production.

AB - Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) preand post-resistance training. Subjects were genotyped for NR3C1-2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3 ±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes.We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol's actions in muscle tissue as they interact with sex differences in cortisol production.

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Glucocorticoid receptor (NR3C1) variants associate with the muscle strength and size response to resistance training

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