Glucose biosensor based on immobilization of glucose oxidase in platinum nanoparticles/graphene/chitosan nanocomposite film

Hong Wu, Jun Wang, Xinhuang Kang, Chongmin Wang, Donghai Wang, Jun Liu, Ilhan A. Aksay, Yuehe Lin

Research output: Contribution to journalArticle

329 Scopus citations

Abstract

The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing is described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with a detection limit of 0.6 μM glucose was achieved. The biosensor also has good reproducibility, long-term stability and negligible interfering signals from ascorbic acid and uric acid comparing with the response to glucose. The large surface area and good electrical conductivity of graphene suggests that graphene is a potential candidate as a sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalTalanta
Volume80
Issue number1
DOIs
StatePublished - Nov 15 2009

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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