Glucose transporter expression in brain: Relationship to cerebral glucose utilization

Susan J. Vannucci, Rebekah R. Clark, Ellen Koehler-Stec, Kang Li, Carolyn B. Smith, Peter Davies, Fran Maher, Ian A. Simpson

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Glucose is the principle energy source for mammalian brain. Delivery of glucose from the blood to the brain requires its transport across the endothelial cells of the blood-brain barrier and across the plasma membranes of neurons and glia, which is mediated by the facilitative glucose transporter proteins. The two primary glucose transporter isoforms which function in cerebral glucose metabolism are GLUT1 and GLUT3. GLUT1 is the primary transporter in the blood-brain barrier, choroid plexus, ependyma, and glia; GLUT3 is the neuronal glucose transporter. The levels of expression of both transporters are regulated in concert with metabolic demand and regional rates of cerebral glucose utilization. We present several experimental paradigms in which alterations in energetic demand and/or substrate supply affect glucose transporter expression. These include normal cerebral development in the rat, Alzheimer's disease, neuronal differentiation in vitro, and dehydration in the rat.

Original languageEnglish (US)
Pages (from-to)369-379
Number of pages11
JournalDevelopmental Neuroscience
Volume20
Issue number4-5
DOIs
StatePublished - Oct 1998

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

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