Glucose transporter proteins in brain: Delivery of glucose to neurons and glia

Susan J. Vannucci, Fran Maher, Ian A. Simpson

Research output: Contribution to journalArticle

456 Citations (Scopus)

Abstract

Glucose is the principle energy source for the mammalian brain. Delivery of glucose from the blood to the brain requires transport across the endothelial cells of the blood-brain barrier and into the neurons and glia. The facilitative glucose transporter proteins mediate these processes. The primary isoforms in brain are GLUT1, detected at high concentrations as a highly glycosylated form, (55 kDa) in blood-brain barrier, and also as a less glycosylated, 45 kDa form, present in parenchyma, predominantly glia; GLUT3 in neurons; and GLUT5 in microglia. The rest of the transporter family, GLUTs 2, 4, and 7, have also been detected in brain but at lower levels of expression and confined to more discrete regions. All of the transporters probably contribute to cerebral glucose utilization, as part of overall metabolism and metabolic interactions among cells. We discuss the properties, regulation, cell-specific location, and kinetic characteristics of the isoforms, their potential contributions to cerebral metabolism, and several experimental paradigms in which alterations in energetic demand and/or substrate supply affect glucose transporter expression.

Original languageEnglish (US)
Pages (from-to)2-21
Number of pages20
JournalGlia
Volume21
Issue number1
DOIs
StatePublished - Sep 1 1997

Fingerprint

Facilitative Glucose Transport Proteins
Neuroglia
Neurons
Glucose
Brain
Blood-Brain Barrier
Protein Isoforms
Proteins
Microglia
Cell Communication
Blood Glucose
Endothelial Cells

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Vannucci, Susan J. ; Maher, Fran ; Simpson, Ian A. / Glucose transporter proteins in brain : Delivery of glucose to neurons and glia. In: Glia. 1997 ; Vol. 21, No. 1. pp. 2-21.
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Glucose transporter proteins in brain : Delivery of glucose to neurons and glia. / Vannucci, Susan J.; Maher, Fran; Simpson, Ian A.

In: Glia, Vol. 21, No. 1, 01.09.1997, p. 2-21.

Research output: Contribution to journalArticle

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