Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants

Pao Hwa Lin, Chuhe Chen, Deborah R. Young, Diane Mitchell, Patricia Elmer, Yanfang Wang, Bryan Batch, Catherine Champagne

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The clinical significance of glycemic index (GI) and glycemic load (GL) is inconclusive. Objective: This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD) risk factors including body weight, blood pressure (BP), serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC) change only (p < 0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L) with a significant age interaction. The GL change was significantly associated with TC (p = 0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L) positively and with low density lipoprotein cholesterol (LDL-C) changes negatively (p = 0.03, β = -0.01±0.00 mg/dL or -0.00±0.00 mmol/L), and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

Original languageEnglish (US)
JournalFood and Nutrition Research
Volume56
DOIs
StatePublished - 2012

Fingerprint

Glycemic Index
glycemic index
risk factors
Cholesterol
cholesterol
low density lipoprotein cholesterol
LDL Cholesterol
cardiovascular diseases
blood pressure
Cardiovascular Diseases
Blood Pressure
diet recall
homocysteine
Homocysteine
African Americans
Glycemic Load
eating habits
physical activity
blood lipids
hypertension

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Lin, Pao Hwa ; Chen, Chuhe ; Young, Deborah R. ; Mitchell, Diane ; Elmer, Patricia ; Wang, Yanfang ; Batch, Bryan ; Champagne, Catherine. / Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants. In: Food and Nutrition Research. 2012 ; Vol. 56.
@article{baa9270f47b84e86b4056a6643f511a7,
title = "Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants",
abstract = "Background: The clinical significance of glycemic index (GI) and glycemic load (GL) is inconclusive. Objective: This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD) risk factors including body weight, blood pressure (BP), serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62{\%} females and 34{\%} African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC) change only (p < 0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L) with a significant age interaction. The GL change was significantly associated with TC (p = 0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L) positively and with low density lipoprotein cholesterol (LDL-C) changes negatively (p = 0.03, β = -0.01±0.00 mg/dL or -0.00±0.00 mmol/L), and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.",
author = "Lin, {Pao Hwa} and Chuhe Chen and Young, {Deborah R.} and Diane Mitchell and Patricia Elmer and Yanfang Wang and Bryan Batch and Catherine Champagne",
year = "2012",
doi = "10.3402/fnr.v56i0.9464",
language = "English (US)",
volume = "56",
journal = "Food and Nutrition Research",
issn = "1654-6628",
publisher = "Co-Action Publishing",

}

Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants. / Lin, Pao Hwa; Chen, Chuhe; Young, Deborah R.; Mitchell, Diane; Elmer, Patricia; Wang, Yanfang; Batch, Bryan; Champagne, Catherine.

In: Food and Nutrition Research, Vol. 56, 2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants

AU - Lin, Pao Hwa

AU - Chen, Chuhe

AU - Young, Deborah R.

AU - Mitchell, Diane

AU - Elmer, Patricia

AU - Wang, Yanfang

AU - Batch, Bryan

AU - Champagne, Catherine

PY - 2012

Y1 - 2012

N2 - Background: The clinical significance of glycemic index (GI) and glycemic load (GL) is inconclusive. Objective: This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD) risk factors including body weight, blood pressure (BP), serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC) change only (p < 0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L) with a significant age interaction. The GL change was significantly associated with TC (p = 0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L) positively and with low density lipoprotein cholesterol (LDL-C) changes negatively (p = 0.03, β = -0.01±0.00 mg/dL or -0.00±0.00 mmol/L), and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

AB - Background: The clinical significance of glycemic index (GI) and glycemic load (GL) is inconclusive. Objective: This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD) risk factors including body weight, blood pressure (BP), serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC) change only (p < 0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L) with a significant age interaction. The GL change was significantly associated with TC (p = 0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L) positively and with low density lipoprotein cholesterol (LDL-C) changes negatively (p = 0.03, β = -0.01±0.00 mg/dL or -0.00±0.00 mmol/L), and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

UR - http://www.scopus.com/inward/record.url?scp=84863697440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863697440&partnerID=8YFLogxK

U2 - 10.3402/fnr.v56i0.9464

DO - 10.3402/fnr.v56i0.9464

M3 - Article

C2 - 22675288

AN - SCOPUS:84863697440

VL - 56

JO - Food and Nutrition Research

JF - Food and Nutrition Research

SN - 1654-6628

ER -