Glycogen concentrations and endurance capacity of rats with chronic heart failure

T. I. Musch, R. L. Moore, M. Riedy, P. Burke, Robert Zelis, M. E. Leo, A. Bruno, G. E. Bradford

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The endurance capacities of rats with myocardial infarctions (MI) and of rats having undergone sham operations (SHAM) were tested during a submaximal exercise regimen that consisted of swimming to exhaustion. During this test, a decrement in the endurance capacity of the MI rat was demonstrated as the SHAM rat swam 25% longer than the MI rat (65 ± 4 vs. 52 ± 4 min). Glycogen concentrations were measured in the liver and the white gastrocnemius, plantaris, and soleus muscles of SHAM and MI rats that were randomly divided into four subgroups, which consisted of resting control, swim to exhaustion, swim to exhaustion + 24 h recovery, and swim to exhaustion + 24 h recovery + a second swim to exhaustion. The results demonstrated that the glycogen concentrations found in the liver, white gastrocnemius, plantaris, and soleus muscles of the SHAM and MI rats belonging to the resting control groups were similar. After swimming to exhaustion the glycogen concentrations in these tissues were significantly reduced compared with those found in the resting control groups of rats, and after 24 h of recovery the glycogen concentrations in these tissues were again similar to those found in the resting control groups of rats. Since the magnitude of the glycogen depletion in the liver and the white gastrocnemius, plantaris, and soleus muscles was similar in the SHAM and MI rats and because the SHAM rats consistently swam for longer periods of time in each of the experimental groups, it would be logical to assume that the rates of glycogen utilization for the various tissues may have been greater in the MI rat during exercise. However, since we were not able to accurately assess the rates of glycogen utilization in these tissues, the question of whether or not the early onset of fatigue in the MI rat is associated with increased rates of glycogen depletion in the tissues during exercise remains unanswered.

Original languageEnglish (US)
Pages (from-to)1153-1159
Number of pages7
JournalJournal of Applied Physiology
Volume64
Issue number3
StatePublished - Jan 1 1988

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Glycogen
Heart Failure
Skeletal Muscle
Myocardial Infarction
Control Groups
Liver
Fatigue
salicylhydroxamic acid

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Musch, T. I., Moore, R. L., Riedy, M., Burke, P., Zelis, R., Leo, M. E., ... Bradford, G. E. (1988). Glycogen concentrations and endurance capacity of rats with chronic heart failure. Journal of Applied Physiology, 64(3), 1153-1159.
Musch, T. I. ; Moore, R. L. ; Riedy, M. ; Burke, P. ; Zelis, Robert ; Leo, M. E. ; Bruno, A. ; Bradford, G. E. / Glycogen concentrations and endurance capacity of rats with chronic heart failure. In: Journal of Applied Physiology. 1988 ; Vol. 64, No. 3. pp. 1153-1159.
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Musch, TI, Moore, RL, Riedy, M, Burke, P, Zelis, R, Leo, ME, Bruno, A & Bradford, GE 1988, 'Glycogen concentrations and endurance capacity of rats with chronic heart failure', Journal of Applied Physiology, vol. 64, no. 3, pp. 1153-1159.

Glycogen concentrations and endurance capacity of rats with chronic heart failure. / Musch, T. I.; Moore, R. L.; Riedy, M.; Burke, P.; Zelis, Robert; Leo, M. E.; Bruno, A.; Bradford, G. E.

In: Journal of Applied Physiology, Vol. 64, No. 3, 01.01.1988, p. 1153-1159.

Research output: Contribution to journalArticle

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Musch TI, Moore RL, Riedy M, Burke P, Zelis R, Leo ME et al. Glycogen concentrations and endurance capacity of rats with chronic heart failure. Journal of Applied Physiology. 1988 Jan 1;64(3):1153-1159.