Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans

Lawrence Sinoway, K. J. Wroblewski, S. A. Prophet, Steven Ettinger, K. S. Gray, S. K. Whisler, G. Miller, R. L. Moore

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Post leg exercise circulatory arrest (PLE-CA) raises blood pressure (BP) and reduces peak forearm vascular conductance (C). This reflex is evoked by activation of muscle afferents that are often sensitive to lactic acid. We tested the hypothesis that lactic acid reductions induced by muscle glycogen depletion would attenuate the lower-limb metaboreceptor-mediated pressor and forearm vasoconstrictor responses. Eleven subjects had C measured (plethysmography) during post leg exercise circulatory arrest (PLE-CA) (supine bicycle exercise for 9 min, 10 s at 75% V̇O(2 max) before and after undergoing a glycogen-depletion paradigm (24-h fast followed by 10 min of supine leg exercise at 75% V̇O(2 max)). In six subjects with lower lactate values, C during PLE-CA was higher after glycogen depletion (0.39 ± 0.05 vs. 0.21 ± 0.01 ml · min-1 · 100 ml-1 · mmHg-1; P < 0.01) and BP was lower (113 ± 6 vs. 128 ± 6 mmHg, P < 0.01). In five subjects without attenuated lactate responses, C and BP during PLE-CA were not different. Muscle biopsies (n = 5) demonstrated that the paradigm lowered muscle glycogen concentrations. Thus glycogen depletion-induced reductions in muscle lactate are associated with reduced muscle metaboreceptor-mediated responses.

Original languageEnglish (US)
Pages (from-to)H1499-H1505
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume263
Issue number5 32-5
DOIs
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans'. Together they form a unique fingerprint.

Cite this