Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys

Shannon L. Kelleher, Dereck Chatterton, Karin Nielsen, Bo Lönnerdal

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Advances in dairy technology make it possible to enrich infant formula with specific bovine milk components that may enhance nutrient status. Glycomacropeptide, a carbohydrate-rich casein peptide, may increase absorption of calcium, iron, or zinc. α-Lactalbumin, a major breast-milk protein, may contribute to a balanced amino acid pattern and increase calcium and zinc absorption. Objective: We determined the effects of glycomacropeptide- and α-lactalbumin-supplemented infant formula on growth; trace mineral status; iron, zinc, and calcium absorption; and plasma amino acid, blood urea nitrogen, and plasma insulin concentrations. Design: Infant rhesus monkeys (n = 5 infants per group) were breastfed or fed control or α-lactalbumin- or glycomacropeptide-supplemented formula from birth to 4 mo of age. Hematologic measures and growth were assessed monthly. Mineral absorption was measured with radioisotopes and whole body counting. Results: Infants fed glycomacropeptide had higher food intake than did other formula-fed infants. Infants fed glycomacropeptide or control formula had higher hematocrit values than did infants that were breastfed or fed α-lactalbumin. Infants fed glycomacropeptide or control formula had higher plasma zinc and zinc absorption than did breastfed infants. Where differences were observed, breastfed infants and infants fed α-lactalbumin had similar plasma essential amino acid and insulin profiles, which were different from those of infants fed glycomacropeptide or control formula. Conclusions: Glycomacropeptide- or α-lactalbumin-supplemented formula has no adverse effects on nutritional status in infant monkeys. Glycomacropeptide supplementation increases zinc absorption, which may permit the reduction of formula zinc concentrations, and α-lactalbumin supplementation promotes a plasma amino acid pattern similar to that of breastfed infant monkeys.

Original languageEnglish (US)
Pages (from-to)1261-1268
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume77
Issue number5
StatePublished - May 1 2003

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Lactalbumin
Infant Formula
Macaca mulatta
Nutritional Status
Growth
Zinc
Calcium
Amino Acids
Haplorhini
caseinomacropeptide
Iron
Whole-Body Counting
Insulin
Essential Amino Acids
Milk Proteins
Blood Urea Nitrogen
Trace Elements
Human Milk
Caseins
Hematocrit

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Kelleher, Shannon L. ; Chatterton, Dereck ; Nielsen, Karin ; Lönnerdal, Bo. / Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. In: American Journal of Clinical Nutrition. 2003 ; Vol. 77, No. 5. pp. 1261-1268.
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abstract = "Background: Advances in dairy technology make it possible to enrich infant formula with specific bovine milk components that may enhance nutrient status. Glycomacropeptide, a carbohydrate-rich casein peptide, may increase absorption of calcium, iron, or zinc. α-Lactalbumin, a major breast-milk protein, may contribute to a balanced amino acid pattern and increase calcium and zinc absorption. Objective: We determined the effects of glycomacropeptide- and α-lactalbumin-supplemented infant formula on growth; trace mineral status; iron, zinc, and calcium absorption; and plasma amino acid, blood urea nitrogen, and plasma insulin concentrations. Design: Infant rhesus monkeys (n = 5 infants per group) were breastfed or fed control or α-lactalbumin- or glycomacropeptide-supplemented formula from birth to 4 mo of age. Hematologic measures and growth were assessed monthly. Mineral absorption was measured with radioisotopes and whole body counting. Results: Infants fed glycomacropeptide had higher food intake than did other formula-fed infants. Infants fed glycomacropeptide or control formula had higher hematocrit values than did infants that were breastfed or fed α-lactalbumin. Infants fed glycomacropeptide or control formula had higher plasma zinc and zinc absorption than did breastfed infants. Where differences were observed, breastfed infants and infants fed α-lactalbumin had similar plasma essential amino acid and insulin profiles, which were different from those of infants fed glycomacropeptide or control formula. Conclusions: Glycomacropeptide- or α-lactalbumin-supplemented formula has no adverse effects on nutritional status in infant monkeys. Glycomacropeptide supplementation increases zinc absorption, which may permit the reduction of formula zinc concentrations, and α-lactalbumin supplementation promotes a plasma amino acid pattern similar to that of breastfed infant monkeys.",
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Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. / Kelleher, Shannon L.; Chatterton, Dereck; Nielsen, Karin; Lönnerdal, Bo.

In: American Journal of Clinical Nutrition, Vol. 77, No. 5, 01.05.2003, p. 1261-1268.

Research output: Contribution to journalArticle

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T1 - Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys

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AU - Lönnerdal, Bo

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N2 - Background: Advances in dairy technology make it possible to enrich infant formula with specific bovine milk components that may enhance nutrient status. Glycomacropeptide, a carbohydrate-rich casein peptide, may increase absorption of calcium, iron, or zinc. α-Lactalbumin, a major breast-milk protein, may contribute to a balanced amino acid pattern and increase calcium and zinc absorption. Objective: We determined the effects of glycomacropeptide- and α-lactalbumin-supplemented infant formula on growth; trace mineral status; iron, zinc, and calcium absorption; and plasma amino acid, blood urea nitrogen, and plasma insulin concentrations. Design: Infant rhesus monkeys (n = 5 infants per group) were breastfed or fed control or α-lactalbumin- or glycomacropeptide-supplemented formula from birth to 4 mo of age. Hematologic measures and growth were assessed monthly. Mineral absorption was measured with radioisotopes and whole body counting. Results: Infants fed glycomacropeptide had higher food intake than did other formula-fed infants. Infants fed glycomacropeptide or control formula had higher hematocrit values than did infants that were breastfed or fed α-lactalbumin. Infants fed glycomacropeptide or control formula had higher plasma zinc and zinc absorption than did breastfed infants. Where differences were observed, breastfed infants and infants fed α-lactalbumin had similar plasma essential amino acid and insulin profiles, which were different from those of infants fed glycomacropeptide or control formula. Conclusions: Glycomacropeptide- or α-lactalbumin-supplemented formula has no adverse effects on nutritional status in infant monkeys. Glycomacropeptide supplementation increases zinc absorption, which may permit the reduction of formula zinc concentrations, and α-lactalbumin supplementation promotes a plasma amino acid pattern similar to that of breastfed infant monkeys.

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