Glycoproteins and human cancer: II. Correlation between circulating level and disease status

Harold Harvey, Allan Lipton, Deborah White, Eugene Davidson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Many cancer patients have elevated serum protein and sialic acid (N‐acetyl neuraminic acid, NANA) levels. Serial determinations were performed, using serum treated with perchloric acid from 34 patients with widespread metastatic disease. Six of six patients who underwent debulking surgery had a drop in their serum NANA value to normal levels following a transient rise in the immediate postoperative period. Twenty‐eight patients received chemotherapy and had serial NANA determinations over periods ranging from 4 to 12 months. Eleven of 28 patients demonstrated tumor regression or stable disease. Ten of the 11 in this group had a drop in their serum NANA level. The remaining 17 patients showed tumor progression, and serum NANA rose in 11 of 12 patients with widespread progression of metastatic disease. This elevation preceded clinical relapse in 8 of the 11 patients. Elevation did not occur in four of five patients with a local site relapse of disease (two chest wall, one lung mass, one brain metastases). Serial serum glycoprotein titers deserve further consideration as a monitor of response to chemotherapy of metastatic disease.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalCancer
Volume47
Issue number2
DOIs
StatePublished - Jan 1 1981

Fingerprint

Neuraminic Acids
Neoplasms
Serum
human ITGA2B protein
Recurrence
Drug Therapy
Thoracic Wall
N-Acetylneuraminic Acid
Postoperative Period
Disease Progression
Blood Proteins
Glycoproteins
Reference Values
Neoplasm Metastasis
Lung
Brain

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{f7bfe83d8f36492b9d2978577c6ec3e8,
title = "Glycoproteins and human cancer: II. Correlation between circulating level and disease status",
abstract = "Many cancer patients have elevated serum protein and sialic acid (N‐acetyl neuraminic acid, NANA) levels. Serial determinations were performed, using serum treated with perchloric acid from 34 patients with widespread metastatic disease. Six of six patients who underwent debulking surgery had a drop in their serum NANA value to normal levels following a transient rise in the immediate postoperative period. Twenty‐eight patients received chemotherapy and had serial NANA determinations over periods ranging from 4 to 12 months. Eleven of 28 patients demonstrated tumor regression or stable disease. Ten of the 11 in this group had a drop in their serum NANA level. The remaining 17 patients showed tumor progression, and serum NANA rose in 11 of 12 patients with widespread progression of metastatic disease. This elevation preceded clinical relapse in 8 of the 11 patients. Elevation did not occur in four of five patients with a local site relapse of disease (two chest wall, one lung mass, one brain metastases). Serial serum glycoprotein titers deserve further consideration as a monitor of response to chemotherapy of metastatic disease.",
author = "Harold Harvey and Allan Lipton and Deborah White and Eugene Davidson",
year = "1981",
month = "1",
day = "1",
doi = "10.1002/1097-0142(19810115)47:2<324::AID-CNCR2820470219>3.0.CO;2-L",
language = "English (US)",
volume = "47",
pages = "324--327",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

Glycoproteins and human cancer : II. Correlation between circulating level and disease status. / Harvey, Harold; Lipton, Allan; White, Deborah; Davidson, Eugene.

In: Cancer, Vol. 47, No. 2, 01.01.1981, p. 324-327.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glycoproteins and human cancer

T2 - II. Correlation between circulating level and disease status

AU - Harvey, Harold

AU - Lipton, Allan

AU - White, Deborah

AU - Davidson, Eugene

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Many cancer patients have elevated serum protein and sialic acid (N‐acetyl neuraminic acid, NANA) levels. Serial determinations were performed, using serum treated with perchloric acid from 34 patients with widespread metastatic disease. Six of six patients who underwent debulking surgery had a drop in their serum NANA value to normal levels following a transient rise in the immediate postoperative period. Twenty‐eight patients received chemotherapy and had serial NANA determinations over periods ranging from 4 to 12 months. Eleven of 28 patients demonstrated tumor regression or stable disease. Ten of the 11 in this group had a drop in their serum NANA level. The remaining 17 patients showed tumor progression, and serum NANA rose in 11 of 12 patients with widespread progression of metastatic disease. This elevation preceded clinical relapse in 8 of the 11 patients. Elevation did not occur in four of five patients with a local site relapse of disease (two chest wall, one lung mass, one brain metastases). Serial serum glycoprotein titers deserve further consideration as a monitor of response to chemotherapy of metastatic disease.

AB - Many cancer patients have elevated serum protein and sialic acid (N‐acetyl neuraminic acid, NANA) levels. Serial determinations were performed, using serum treated with perchloric acid from 34 patients with widespread metastatic disease. Six of six patients who underwent debulking surgery had a drop in their serum NANA value to normal levels following a transient rise in the immediate postoperative period. Twenty‐eight patients received chemotherapy and had serial NANA determinations over periods ranging from 4 to 12 months. Eleven of 28 patients demonstrated tumor regression or stable disease. Ten of the 11 in this group had a drop in their serum NANA level. The remaining 17 patients showed tumor progression, and serum NANA rose in 11 of 12 patients with widespread progression of metastatic disease. This elevation preceded clinical relapse in 8 of the 11 patients. Elevation did not occur in four of five patients with a local site relapse of disease (two chest wall, one lung mass, one brain metastases). Serial serum glycoprotein titers deserve further consideration as a monitor of response to chemotherapy of metastatic disease.

UR - http://www.scopus.com/inward/record.url?scp=0019350743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019350743&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19810115)47:2<324::AID-CNCR2820470219>3.0.CO;2-L

DO - 10.1002/1097-0142(19810115)47:2<324::AID-CNCR2820470219>3.0.CO;2-L

M3 - Article

C2 - 7459820

AN - SCOPUS:0019350743

VL - 47

SP - 324

EP - 327

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 2

ER -