Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia

Lawrence Aguis, Maria Hadjiconstantinou, Zan Xi Qu, Norton H. Neff, Dennis K. Pearl, Allan J. Yates

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rat pups, seven days old, with right carotid artery ligations were exposed to an atmosphere of oxygen 8% remainder nitrogen for 2 hr. The animals that survived for three weeks after the hypoxic-ischemic episode had clusters of darkly stained (hematoxylin-eosin) neurons in the cortex and reduced uptake of dopamine (frontal cortex) and choline (frontal cortex, hippocampus and striatum) in preparations of synaptosomes. Treatment with GM1 ganglioside partially corrected the loss of uptake activity and increased the number of darkly stained neurons.

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalInternational Journal of Developmental Neuroscience
Volume12
Issue number7
DOIs
StatePublished - Nov 1994

Fingerprint

Gangliosides
Frontal Lobe
Ischemia
Staining and Labeling
G(M1) Ganglioside
Neurons
Synaptosomes
Brain
Hematoxylin
Eosine Yellowish-(YS)
Choline
Atmosphere
Carotid Arteries
Ligation
Hippocampus
Dopamine
Nitrogen
Oxygen
Hypoxia

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Cite this

Aguis, Lawrence ; Hadjiconstantinou, Maria ; Qu, Zan Xi ; Neff, Norton H. ; Pearl, Dennis K. ; Yates, Allan J. / Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia. In: International Journal of Developmental Neuroscience. 1994 ; Vol. 12, No. 7. pp. 623-630.
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Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia. / Aguis, Lawrence; Hadjiconstantinou, Maria; Qu, Zan Xi; Neff, Norton H.; Pearl, Dennis K.; Yates, Allan J.

In: International Journal of Developmental Neuroscience, Vol. 12, No. 7, 11.1994, p. 623-630.

Research output: Contribution to journalArticle

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