GOAT links dietary lipids with the endocrine control of energy balance

Henriette Kirchner, Jesus A. Gutierrez, Patricia J. Solenberg, Paul T. Pfluger, Traci A. Czyzyk, Jill A. Willency, Annette Schürmann, Hans Georg Joost, Ronald J. Jandacek, John E. Hale, Mark L. Heiman, Matthias H. Tschöp

Research output: Contribution to journalArticlepeer-review

313 Scopus citations

Abstract

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalNature Medicine
Volume15
Issue number7
DOIs
StatePublished - Jul 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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