Gold and silver nanoparticle-assisted laser desorption ionization mass spectrometry compatible with secondary ion mass spectrometry for lipid analysis

Amir Saeid Mohammadi, John S. Fletcher, Per Malmberg, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

To provide a convenient organic matrix-free spray-on sample preparation for laser desorption ionization (LDI) that is compatible with secondary ion mass spectrometry (SIMS) imaging mass spectrometry (IMS) techniques, silver and gold nanoparticles (NPs) were applied on a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid sample. Application of Ag and Au nanoparticles to the POPC sample allowed POPC lipid fragments to be detected using NP-LDI in both positive and negative polarities. In addition, the same sample prepared for NP-LDI experiments was used for C60 SIMS lipid analysis, and a secondary ion signal enhancement was obtained for the [M+H]+ ion of the POPC lipid as well as for characteristics POPC lipid fragments in positive ion mode.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalSurface and Interface Analysis
Volume46
Issue numberS1
DOIs
StatePublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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