Gonadal hormones and semen quality in male runners: A volume threshold effect of endurance training

Mary Jane De Souza, J. C. Arce, L. S. Pescatello, H. S. Scherzer, A. A. Luciano

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Eleven high mileage runners (HR) (108.0 ± 4.5 km·wk-1), 9 moderate mileage runners (MR) (54.2 ± 3.7 km·wk-1) and 10 sedentary controls (SC) of similar age (28.3 ± 1.5 yr) were studied to evaluate the effects of volume of endurance training on reproductive function in male runners. Levels of reproductive, adrenal and thyroid hormones were measured during a 1-hr period of serial blood sampling (q20 min) and urinary excretion of 24-hr luteinizing hormone (uLH) was determined on two separate days. Semen exams and sperm penetration of standard cervical mucus (Penetrak) were performed 2-5 times. Levels of total testosterone (TT) and free testosterone (FT) were significantly lower in HR (15.3 ± 1.3 nmol·l-1 and 60.2 ± 5.1 pmol·l-1) compared to MR (21.4 ± 1.6 nmol·l-1 and 86.0 ± 6.1 pmol·l-1) and SC (19.5 ± 0.9 nmol·l-1 and 75.9 ± 3.6 pmol·l-1). No differences (p > 0.05) were found in uLH, serum LH, follicle-stimulating hormone (FSH), and prolactin (PRL) among the three groups. No other hormonal differences (p > 0.05) were observed among the groups. Total motile sperm count and density were lower (p < 0.05) in HR than SC. Decreased (p < 0.0006) sperm motility and an increased (p < 0.004) population of immature sperm and round cells were observed in HR compared to MR and SC. Sperm penetration of bovine cervical mucus was also decreased (p < 0.024) in HR compared to SC. Volume of training, defined by km·wk-1 run, was significantly correlated to sperm motility, density and number of round cells. TT was significantly correlated to number of round cells. These findings suggest that well defined differences in reproductive function exist between HR and MR, including decreased gonadal steroids and disturbed semen quality that is not observed in runners participating in more moderate volumes of training. Thus, a 'volume-threshold' effect of training is apparently coincident with high volumes of endurance running.

Original languageEnglish (US)
Pages (from-to)383-391
Number of pages9
JournalInternational Journal of Sports Medicine
Volume15
Issue number7
StatePublished - Jan 1 1994

Fingerprint

Gonadal Hormones
Semen Analysis
Sperm-Ovum Interactions
Cervix Mucus
Testosterone
Sperm Count
Sperm Motility
Follicle Stimulating Hormone
Luteinizing Hormone
Semen
Thyroid Hormones
Prolactin
Spermatozoa
Cell Count
Steroids
Serum
Population

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

De Souza, Mary Jane ; Arce, J. C. ; Pescatello, L. S. ; Scherzer, H. S. ; Luciano, A. A. / Gonadal hormones and semen quality in male runners : A volume threshold effect of endurance training. In: International Journal of Sports Medicine. 1994 ; Vol. 15, No. 7. pp. 383-391.
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abstract = "Eleven high mileage runners (HR) (108.0 ± 4.5 km·wk-1), 9 moderate mileage runners (MR) (54.2 ± 3.7 km·wk-1) and 10 sedentary controls (SC) of similar age (28.3 ± 1.5 yr) were studied to evaluate the effects of volume of endurance training on reproductive function in male runners. Levels of reproductive, adrenal and thyroid hormones were measured during a 1-hr period of serial blood sampling (q20 min) and urinary excretion of 24-hr luteinizing hormone (uLH) was determined on two separate days. Semen exams and sperm penetration of standard cervical mucus (Penetrak) were performed 2-5 times. Levels of total testosterone (TT) and free testosterone (FT) were significantly lower in HR (15.3 ± 1.3 nmol·l-1 and 60.2 ± 5.1 pmol·l-1) compared to MR (21.4 ± 1.6 nmol·l-1 and 86.0 ± 6.1 pmol·l-1) and SC (19.5 ± 0.9 nmol·l-1 and 75.9 ± 3.6 pmol·l-1). No differences (p > 0.05) were found in uLH, serum LH, follicle-stimulating hormone (FSH), and prolactin (PRL) among the three groups. No other hormonal differences (p > 0.05) were observed among the groups. Total motile sperm count and density were lower (p < 0.05) in HR than SC. Decreased (p < 0.0006) sperm motility and an increased (p < 0.004) population of immature sperm and round cells were observed in HR compared to MR and SC. Sperm penetration of bovine cervical mucus was also decreased (p < 0.024) in HR compared to SC. Volume of training, defined by km·wk-1 run, was significantly correlated to sperm motility, density and number of round cells. TT was significantly correlated to number of round cells. These findings suggest that well defined differences in reproductive function exist between HR and MR, including decreased gonadal steroids and disturbed semen quality that is not observed in runners participating in more moderate volumes of training. Thus, a 'volume-threshold' effect of training is apparently coincident with high volumes of endurance running.",
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Gonadal hormones and semen quality in male runners : A volume threshold effect of endurance training. / De Souza, Mary Jane; Arce, J. C.; Pescatello, L. S.; Scherzer, H. S.; Luciano, A. A.

In: International Journal of Sports Medicine, Vol. 15, No. 7, 01.01.1994, p. 383-391.

Research output: Contribution to journalArticle

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T1 - Gonadal hormones and semen quality in male runners

T2 - A volume threshold effect of endurance training

AU - De Souza, Mary Jane

AU - Arce, J. C.

AU - Pescatello, L. S.

AU - Scherzer, H. S.

AU - Luciano, A. A.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Eleven high mileage runners (HR) (108.0 ± 4.5 km·wk-1), 9 moderate mileage runners (MR) (54.2 ± 3.7 km·wk-1) and 10 sedentary controls (SC) of similar age (28.3 ± 1.5 yr) were studied to evaluate the effects of volume of endurance training on reproductive function in male runners. Levels of reproductive, adrenal and thyroid hormones were measured during a 1-hr period of serial blood sampling (q20 min) and urinary excretion of 24-hr luteinizing hormone (uLH) was determined on two separate days. Semen exams and sperm penetration of standard cervical mucus (Penetrak) were performed 2-5 times. Levels of total testosterone (TT) and free testosterone (FT) were significantly lower in HR (15.3 ± 1.3 nmol·l-1 and 60.2 ± 5.1 pmol·l-1) compared to MR (21.4 ± 1.6 nmol·l-1 and 86.0 ± 6.1 pmol·l-1) and SC (19.5 ± 0.9 nmol·l-1 and 75.9 ± 3.6 pmol·l-1). No differences (p > 0.05) were found in uLH, serum LH, follicle-stimulating hormone (FSH), and prolactin (PRL) among the three groups. No other hormonal differences (p > 0.05) were observed among the groups. Total motile sperm count and density were lower (p < 0.05) in HR than SC. Decreased (p < 0.0006) sperm motility and an increased (p < 0.004) population of immature sperm and round cells were observed in HR compared to MR and SC. Sperm penetration of bovine cervical mucus was also decreased (p < 0.024) in HR compared to SC. Volume of training, defined by km·wk-1 run, was significantly correlated to sperm motility, density and number of round cells. TT was significantly correlated to number of round cells. These findings suggest that well defined differences in reproductive function exist between HR and MR, including decreased gonadal steroids and disturbed semen quality that is not observed in runners participating in more moderate volumes of training. Thus, a 'volume-threshold' effect of training is apparently coincident with high volumes of endurance running.

AB - Eleven high mileage runners (HR) (108.0 ± 4.5 km·wk-1), 9 moderate mileage runners (MR) (54.2 ± 3.7 km·wk-1) and 10 sedentary controls (SC) of similar age (28.3 ± 1.5 yr) were studied to evaluate the effects of volume of endurance training on reproductive function in male runners. Levels of reproductive, adrenal and thyroid hormones were measured during a 1-hr period of serial blood sampling (q20 min) and urinary excretion of 24-hr luteinizing hormone (uLH) was determined on two separate days. Semen exams and sperm penetration of standard cervical mucus (Penetrak) were performed 2-5 times. Levels of total testosterone (TT) and free testosterone (FT) were significantly lower in HR (15.3 ± 1.3 nmol·l-1 and 60.2 ± 5.1 pmol·l-1) compared to MR (21.4 ± 1.6 nmol·l-1 and 86.0 ± 6.1 pmol·l-1) and SC (19.5 ± 0.9 nmol·l-1 and 75.9 ± 3.6 pmol·l-1). No differences (p > 0.05) were found in uLH, serum LH, follicle-stimulating hormone (FSH), and prolactin (PRL) among the three groups. No other hormonal differences (p > 0.05) were observed among the groups. Total motile sperm count and density were lower (p < 0.05) in HR than SC. Decreased (p < 0.0006) sperm motility and an increased (p < 0.004) population of immature sperm and round cells were observed in HR compared to MR and SC. Sperm penetration of bovine cervical mucus was also decreased (p < 0.024) in HR compared to SC. Volume of training, defined by km·wk-1 run, was significantly correlated to sperm motility, density and number of round cells. TT was significantly correlated to number of round cells. These findings suggest that well defined differences in reproductive function exist between HR and MR, including decreased gonadal steroids and disturbed semen quality that is not observed in runners participating in more moderate volumes of training. Thus, a 'volume-threshold' effect of training is apparently coincident with high volumes of endurance running.

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