Granulosa Cell Apoptosis

Conservation of Cell Signaling in an Avian Ovarian Model System

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Ovarian follicle atresia in all vertebrates studied to date is mediated via apoptosis, a process that is often initiated within the granulosa cell layer. While follicle atresia is considered a normal physiological process to insure the greatest chance for ovulation of fertilizable oocytes, abnormally high rates of atresia result in chronic infertility and/or premature termination of fertility (e.g., menopause). Although the vast majority of research to elucidate the molecular ordering of cell signaling during the process of granulosa cell apoptosis has been conducted in mammalian model systems, there is ample evidence to demonstrate that many of the proteins, enzymes and cell-signaling pathways are common to ovarian follicles from avian species. The following review will discuss evidence for the conservation of cellular processes that regulate the fate of granulosa cells from the avian, versus mammalian, ovary during follicle development.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalNeuroSignals
Volume9
Issue number2
DOIs
StatePublished - May 10 2000

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Granulosa Cells
Ovarian Follicle
Apoptosis
Physiological Phenomena
Menopause
Ovulation
Infertility
Oocytes
Fertility
Vertebrates
Ovary
Enzymes
Research
Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

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title = "Granulosa Cell Apoptosis: Conservation of Cell Signaling in an Avian Ovarian Model System",
abstract = "Ovarian follicle atresia in all vertebrates studied to date is mediated via apoptosis, a process that is often initiated within the granulosa cell layer. While follicle atresia is considered a normal physiological process to insure the greatest chance for ovulation of fertilizable oocytes, abnormally high rates of atresia result in chronic infertility and/or premature termination of fertility (e.g., menopause). Although the vast majority of research to elucidate the molecular ordering of cell signaling during the process of granulosa cell apoptosis has been conducted in mammalian model systems, there is ample evidence to demonstrate that many of the proteins, enzymes and cell-signaling pathways are common to ovarian follicles from avian species. The following review will discuss evidence for the conservation of cellular processes that regulate the fate of granulosa cells from the avian, versus mammalian, ovary during follicle development.",
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Granulosa Cell Apoptosis : Conservation of Cell Signaling in an Avian Ovarian Model System. / Johnson, Alan Leslie.

In: NeuroSignals, Vol. 9, No. 2, 10.05.2000, p. 96-101.

Research output: Contribution to journalArticle

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