TY - JOUR
T1 - Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder
AU - Marshall, David F.
AU - Walker, Sara J.
AU - Ryan, Kelly A.
AU - Kamali, Masoud
AU - Saunders, Erika F.H.
AU - Weldon, Anne L.
AU - Adams, Kenneth M.
AU - McInnis, Melvin G.
AU - Langenecker, Scott A.
PY - 2012/12/30
Y1 - 2012/12/30
N2 - Measures of cognitive dysfunction in Bipolar Disorder (BD) have identified state and trait dependent metrics. An influence of substance abuse (SUD) on BD has been suggested. This study investigates potential differential, additive, or interactive cognitive dysfunction in bipolar patients with or without a history of SUD. Two hundred fifty-six individuals with BD, 98 without SUD and 158 with SUD, and 97 Healthy Controls (HC) completed diagnostic interviews, neuropsychological testing, and symptom severity scales. The BD groups exhibited poorer performance than the HC group on most cognitive factors. The BD with SUD exhibited significantly poorer performance than BD without SUD in visual memory and conceptual reasoning/set-shifting. In addition, a significant interaction effect between substance use and depressive symptoms was found for auditory memory and emotion processing. BD patients with a history of SUD demonstrated worse visual memory and conceptual reasoning skills above and beyond the dysfunction observed in these domains among individuals with BD without SUD, suggesting greater impact on integrative, gestalt-driven processing domains. Future research might address longitudinal outcome as a function of BD, SUD, and combined BD/SUD to evaluate neural systems involved in risk for, and effects of, these illnesses.
AB - Measures of cognitive dysfunction in Bipolar Disorder (BD) have identified state and trait dependent metrics. An influence of substance abuse (SUD) on BD has been suggested. This study investigates potential differential, additive, or interactive cognitive dysfunction in bipolar patients with or without a history of SUD. Two hundred fifty-six individuals with BD, 98 without SUD and 158 with SUD, and 97 Healthy Controls (HC) completed diagnostic interviews, neuropsychological testing, and symptom severity scales. The BD groups exhibited poorer performance than the HC group on most cognitive factors. The BD with SUD exhibited significantly poorer performance than BD without SUD in visual memory and conceptual reasoning/set-shifting. In addition, a significant interaction effect between substance use and depressive symptoms was found for auditory memory and emotion processing. BD patients with a history of SUD demonstrated worse visual memory and conceptual reasoning skills above and beyond the dysfunction observed in these domains among individuals with BD without SUD, suggesting greater impact on integrative, gestalt-driven processing domains. Future research might address longitudinal outcome as a function of BD, SUD, and combined BD/SUD to evaluate neural systems involved in risk for, and effects of, these illnesses.
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UR - http://www.scopus.com/inward/citedby.url?scp=84872411473&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2012.06.013
DO - 10.1016/j.psychres.2012.06.013
M3 - Article
C2 - 22769049
AN - SCOPUS:84872411473
SN - 0165-1781
VL - 200
SP - 252
EP - 257
JO - Psychiatry Research
JF - Psychiatry Research
IS - 2-3
ER -
