Green Tea Polyphenols Inhibit Colorectal Tumorigenesis in Azoxymethane-Treated F344 Rats

Xingpei Hao, Hang Xiao, Jihyeung Ju, Mao Jung Lee, Joshua D. Lambert, Chung S. Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In studying the cancer-preventive activities of green tea polyphenols, we previously demonstrated that dietary administration of polyphenon E (PPE) inhibited the formation of aberrant crypt foci (ACF) in the colon of azoxymethane (AOM)-treated F344 rats. Herein, we reported cancer-preventive activity of PPE using colorectal cancer as an end point. F344 rats were given two weekly injections of AOM, and then maintained on a 20% high-fat diet with or without 0.24% PPE for 34 wk. In the control group, 83% of rats developed colorectal tumors. Dietary PPE treatment significantly increased the plasma and colonic levels of tea polyphenols, and decreased tumor multiplicity and tumor size. Histological analysis indicated that PPE significantly decreased the incidence of adenocarcinoma, and the multiplicity of adenocarcinoma as well as the multiplicity of adenoma. PPE treatment significantly decreased plasma levels of proinflammatory eicosanoids, prostaglandin E2, and leukotriene B4. It also decreased β-catenin nuclear expression, induced apoptosis, and increased expression levels of RXRα, β, and γ in adenocarcinomas. In conclusion, our results convincingly demonstrated the inhibitory effects of orally administered PPE on colon carcinogenesis in AOM-treated rats and suggested possible biomarkers for the biological effects of green tea polyphenols.

Original languageEnglish (US)
Pages (from-to)623-631
Number of pages9
JournalNutrition and cancer
Volume69
Issue number4
DOIs
StatePublished - May 19 2017

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Azoxymethane
Inbred F344 Rats
Polyphenols
Tea
Carcinogenesis
Adenocarcinoma
Colorectal Neoplasms
Neoplasms
Colon
Aberrant Crypt Foci
Catenins
Leukotriene B4
Eicosanoids
High Fat Diet
polyphenon E
Dinoprostone
Adenoma
Biomarkers
Apoptosis
Control Groups

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Hao, Xingpei ; Xiao, Hang ; Ju, Jihyeung ; Lee, Mao Jung ; Lambert, Joshua D. ; Yang, Chung S. / Green Tea Polyphenols Inhibit Colorectal Tumorigenesis in Azoxymethane-Treated F344 Rats. In: Nutrition and cancer. 2017 ; Vol. 69, No. 4. pp. 623-631.
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Green Tea Polyphenols Inhibit Colorectal Tumorigenesis in Azoxymethane-Treated F344 Rats. / Hao, Xingpei; Xiao, Hang; Ju, Jihyeung; Lee, Mao Jung; Lambert, Joshua D.; Yang, Chung S.

In: Nutrition and cancer, Vol. 69, No. 4, 19.05.2017, p. 623-631.

Research output: Contribution to journalArticle

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