TY - JOUR
T1 - Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration
AU - Lee, Peter A.
AU - Blizzard, Robert M.
AU - Cheek, Donald B.
AU - Holt, A. Barry
N1 - Funding Information:
From rhe Department of Pediatrics, Johns Hopkins University and School of Medicine, Baltimore. Md. Received for publication January 5. 1974. Supported by NIH Grant HD-01852 and NIH Traineeship Grant TI-AM-5219. The patients were studied on the Pediatric Clinical Research Unit. supported by NIH Grant 5-MOI-RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources. o 1974 by Grune & Stratton, Inc.
PY - 1974/10
Y1 - 1974/10
N2 - The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.
AB - The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.
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U2 - 10.1016/0026-0495(74)90040-7
DO - 10.1016/0026-0495(74)90040-7
M3 - Article
C2 - 4370058
AN - SCOPUS:0016277666
SN - 0026-0495
VL - 23
SP - 913
EP - 919
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 10
ER -
