Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration

Peter Lee, Robert M. Blizzard, Donald B. Cheek, A. Barry Holt

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalMetabolism
Volume23
Issue number10
DOIs
StatePublished - Jan 1 1974

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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