The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism