Abstract
Cultured preadipose 3T3 cells are induced or enabled to undergo adipose conversion in the presence of an extract of pituitary gland. Adipogenic activity is found in standard growth hormone preparations derived from different species. Further purification of rat growth hormone by several methods does not remove its adipogenic activity. Human growth hormone synthesized in Escherichia coli is also effective. Adipogenic activity is not associated with other pituitary polypeptides. Since growth hormone acts on preadipose cells in the absence of any other cell type, a mechanism exists for the direct participation of the pituitary gland in the regulation of this form of mesenchymal differentiation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 783-789 |
| Number of pages | 7 |
| Journal | Cell |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1982 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Growth hormone and the adipose conversion of 3T3 cells. / Morikawa, Minoru; Nixon, Tracy; Green, Howard.
In: Cell, Vol. 29, No. 3, 07.1982, p. 783-789.Research output: Contribution to journal › Article
TY - JOUR
T1 - Growth hormone and the adipose conversion of 3T3 cells
AU - Morikawa, Minoru
AU - Nixon, Tracy
AU - Green, Howard
PY - 1982/7
Y1 - 1982/7
N2 - Cultured preadipose 3T3 cells are induced or enabled to undergo adipose conversion in the presence of an extract of pituitary gland. Adipogenic activity is found in standard growth hormone preparations derived from different species. Further purification of rat growth hormone by several methods does not remove its adipogenic activity. Human growth hormone synthesized in Escherichia coli is also effective. Adipogenic activity is not associated with other pituitary polypeptides. Since growth hormone acts on preadipose cells in the absence of any other cell type, a mechanism exists for the direct participation of the pituitary gland in the regulation of this form of mesenchymal differentiation.
AB - Cultured preadipose 3T3 cells are induced or enabled to undergo adipose conversion in the presence of an extract of pituitary gland. Adipogenic activity is found in standard growth hormone preparations derived from different species. Further purification of rat growth hormone by several methods does not remove its adipogenic activity. Human growth hormone synthesized in Escherichia coli is also effective. Adipogenic activity is not associated with other pituitary polypeptides. Since growth hormone acts on preadipose cells in the absence of any other cell type, a mechanism exists for the direct participation of the pituitary gland in the regulation of this form of mesenchymal differentiation.
UR - http://www.scopus.com/inward/record.url?scp=0019966908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019966908&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(82)90440-8
DO - 10.1016/0092-8674(82)90440-8
M3 - Article
C2 - 7151170
AN - SCOPUS:0019966908
VL - 29
SP - 783
EP - 789
JO - Cell
JF - Cell
SN - 0092-8674
IS - 3
ER -