Gustatory neural responses during sodium appetite induced by three different regimens

Ralph Norgren, K. Nakamura, R. Tamura

Research output: Contribution to journalArticle

Abstract

Dietary sodium deprivation induces salt appetite and alters the responsiveness of gustatory neurons to NaCl solutions. We replicated this experiment while recording from the nucleus of the solitary tract of chronically prepared rats using diet, diuretic, or a hormone to raise the appetite. As in previous experiments, dietary deprivation reduced the response magnitude of NaCl-best taste neurons but, unlike in those reports, the effect was relatively non-specific. The mean response to NaCl, sucrose, citric acid, and quinine all decreased by roughly the same amount (range 41.84%). In addition, the mean responses of sucrose-best cells also were reduced. When we used a diuretic, furosemide, to induce an appetite in a similar preparation, NaCl-best neurons responded more, rather than less, and the effect was specific to NaCl. Intraventricular injections of renin also induce salt appetite. This regimen resulted in a modest reduction in the response of NaCl-best neurons to NaCl, but only at higher concentrations (0.3 and 1.0 M). (Supported by NIH MH 3787, DC 00240, and MH 00653.).

Original languageEnglish (US)
Number of pages1
JournalAppetite
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1995

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Appetite
Sodium
Neurons
Diuretics
Sucrose
Salts
Intraventricular Injections
Dietary Sodium
Solitary Nucleus
Quinine
Furosemide
Renin
Citric Acid
Hormones
Diet

All Science Journal Classification (ASJC) codes

  • Psychology(all)
  • Nutrition and Dietetics

Cite this

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abstract = "Dietary sodium deprivation induces salt appetite and alters the responsiveness of gustatory neurons to NaCl solutions. We replicated this experiment while recording from the nucleus of the solitary tract of chronically prepared rats using diet, diuretic, or a hormone to raise the appetite. As in previous experiments, dietary deprivation reduced the response magnitude of NaCl-best taste neurons but, unlike in those reports, the effect was relatively non-specific. The mean response to NaCl, sucrose, citric acid, and quinine all decreased by roughly the same amount (range 41.84{\%}). In addition, the mean responses of sucrose-best cells also were reduced. When we used a diuretic, furosemide, to induce an appetite in a similar preparation, NaCl-best neurons responded more, rather than less, and the effect was specific to NaCl. Intraventricular injections of renin also induce salt appetite. This regimen resulted in a modest reduction in the response of NaCl-best neurons to NaCl, but only at higher concentrations (0.3 and 1.0 M). (Supported by NIH MH 3787, DC 00240, and MH 00653.).",
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Gustatory neural responses during sodium appetite induced by three different regimens. / Norgren, Ralph; Nakamura, K.; Tamura, R.

In: Appetite, Vol. 24, No. 1, 01.01.1995.

Research output: Contribution to journalArticle

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