Gut microbiome as a novel cardiovascular therapeutic target

Vishal Singh, Beng San Yeoh, Matam Vijay Kumar

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Over the last two decades, our understanding of gut microbiotal composition and its association with intra-intestinal and extra-intestinal diseases including risk factors of cardiovascular disease (CVD) namely metabolic syndrome and atherosclerosis, have been increased exponentially. A pertinent question which often arises in researchers' community is on how to manipulate the gut microbial ecology to 'cure' the cardiovascular risk factors. Accordingly, in this review we summarized the potential strategies, based on our current knowledge on gut microbiota in modulating CVD, how gut microbiota can be therapeutically exploited by targeting their metabolic activity to alleviate the risk factors of CVD.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume27
DOIs
StatePublished - Apr 1 2016

Fingerprint

Cardiovascular Diseases
Intestinal Diseases
Ecology
Atherosclerosis
Therapeutics
Research Personnel
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Singh, Vishal ; Yeoh, Beng San ; Kumar, Matam Vijay. / Gut microbiome as a novel cardiovascular therapeutic target. In: Current Opinion in Pharmacology. 2016 ; Vol. 27. pp. 8-12.
@article{03c20747979645c98cbb3bda42139139,
title = "Gut microbiome as a novel cardiovascular therapeutic target",
abstract = "Over the last two decades, our understanding of gut microbiotal composition and its association with intra-intestinal and extra-intestinal diseases including risk factors of cardiovascular disease (CVD) namely metabolic syndrome and atherosclerosis, have been increased exponentially. A pertinent question which often arises in researchers' community is on how to manipulate the gut microbial ecology to 'cure' the cardiovascular risk factors. Accordingly, in this review we summarized the potential strategies, based on our current knowledge on gut microbiota in modulating CVD, how gut microbiota can be therapeutically exploited by targeting their metabolic activity to alleviate the risk factors of CVD.",
author = "Vishal Singh and Yeoh, {Beng San} and Kumar, {Matam Vijay}",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.coph.2016.01.002",
language = "English (US)",
volume = "27",
pages = "8--12",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",

}

Gut microbiome as a novel cardiovascular therapeutic target. / Singh, Vishal; Yeoh, Beng San; Kumar, Matam Vijay.

In: Current Opinion in Pharmacology, Vol. 27, 01.04.2016, p. 8-12.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Gut microbiome as a novel cardiovascular therapeutic target

AU - Singh, Vishal

AU - Yeoh, Beng San

AU - Kumar, Matam Vijay

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Over the last two decades, our understanding of gut microbiotal composition and its association with intra-intestinal and extra-intestinal diseases including risk factors of cardiovascular disease (CVD) namely metabolic syndrome and atherosclerosis, have been increased exponentially. A pertinent question which often arises in researchers' community is on how to manipulate the gut microbial ecology to 'cure' the cardiovascular risk factors. Accordingly, in this review we summarized the potential strategies, based on our current knowledge on gut microbiota in modulating CVD, how gut microbiota can be therapeutically exploited by targeting their metabolic activity to alleviate the risk factors of CVD.

AB - Over the last two decades, our understanding of gut microbiotal composition and its association with intra-intestinal and extra-intestinal diseases including risk factors of cardiovascular disease (CVD) namely metabolic syndrome and atherosclerosis, have been increased exponentially. A pertinent question which often arises in researchers' community is on how to manipulate the gut microbial ecology to 'cure' the cardiovascular risk factors. Accordingly, in this review we summarized the potential strategies, based on our current knowledge on gut microbiota in modulating CVD, how gut microbiota can be therapeutically exploited by targeting their metabolic activity to alleviate the risk factors of CVD.

UR - http://www.scopus.com/inward/record.url?scp=84961343396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961343396&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2016.01.002

DO - 10.1016/j.coph.2016.01.002

M3 - Review article

VL - 27

SP - 8

EP - 12

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -