B10.A(3R) (H-2Kb) mice infected with lymphocytic choriomeningitis virus (LCMV) or vaccinia virus generate cytotoxic T cells capable of specifically lysing virus-infected macrophage target cells from H-2Kb mutant mice M505 (H-2Kbd), and vice versa. Similarly, virus-immune B10.A(4R) (H-2Kk) T cells specifically lyse infected targets from M523 (H-2Kka), and vice versa. In contrast, virus-specific cytotoxic T cells from neither M504 (H-2Dda) and B10.A(5R) (H-2Dd) nor M506 (H-2Kfa) and B10.M(11R) (H-2Kf) mutually crossreact at the cytotoxic effector-cell level. As far as tested, the crossreactivity patterns between wild-type and mutant K or D specificities are identical for LCMV- and vaccinia virus-immune spleen cells. Although this finding is no proof for either the altered self nor the dual recognition concept of T-cell recognition, it may be compatible with the latter model.
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